background this study aimed to evaluate the effectiveness of intravenous immunoglobulin (ivig) and combination of ivig and methylprednisolone for childhood idiopathic (autoimmune) thrombocytopenia (itp) treatment; in addition investigate the related factors to develop chronic form of under 15 years itp. materials and methods this retrospective study conducted on 88 itp patients that treated wit...

Immune thrombocytopenic purpura is an acquired autoimmune disorder that is the most common cause of thrombocytopenia in children. The endocannabinoid system is involved in immune regulation. We evaluated a common missense variant (CAA/CGG; Q63R) of the gene encoding the cannabinoid receptor type 2 (GeneID 1269) in 190 children with immune thrombocytopenic purpura and 600 healthy controls. The a...

Hematologic abnormali"es are generally present among systemic lupus erythematosus pa"ents. Idiopathic thrombocytopenic purpura can be the first manifesta"on of SLE, followed by other symptoms and signs of disease appearing several years later. Although bleeding due to immune thrombocytopenic purpura is usually mild and occurs in mucocutaneous surfaces, but it may be severe and represent in u...

hepatitis a is common in children and usually is a self-limiting disease.  although extrahepatic and hematological immune manifestations following acute hepatitis a virus (hav) infection have rarely been reported, they are frequently observed in other viral hepatitis. in this paper, we report the case of a 3-year-old girl who developed immune thrombocytopenic purpura (itp) and hemolytic anemia ...

The immune chronic thrombocytopenic purpura is an illness characterized by peripheral thrombocytopenia occurred through a mechanism of early hyper destruction of blood platelets or by deficient platelet synthesis in the medulla. The chronic immune purpura can be primary, autoimmune in nature, thrombocytopenic idiopathic or secondary in the context of other associated pathologies. The idiopathic...

background: immune thrombocytopenic purpura (itp) is an autoimmune disease that can cause bleeding disorders in patients, and presents in acute and chronic forms. the acute form is frequently seen in children, but the chronic form mainly inflicts adults. there are differences and similarities in clinical and laboratory findings of the disease between children and adults. we study these differen...

In order to detect diagnostic clues to identify patients with chronic immune thrombocytopenia which is likely to develop systemic lupus erythematosus (SLE), a retrospective study was conducted. Of 39 patients with chronic immune thrombocytopenia, 4 fulfilled the diagnostic criteria being between 4.5 and 14 years after the initial diagnosis of "idiopathic" thrombocytopenic purpura. The remaining...

Thrombotic thrombocytopenic purpura (TTP) is a rare variant of thrombotic microangiopathy. We report case TTP in Nigerian chronic kidney disease (CKD) patient who was previously on clopidogrel. The features resolved soon after clopidogrel withdrawn. Clopidogrel cardio-protective anti-platelet drug used CKD patients at risk dyspepsia. However, its potential to cause should be recognized and cons...

Immune thrombocytopenic purpura is an autoimmune disease characterized by auto-antibody induced platelet destruction and reduced platelet production, leading to low blood platelet count. In this case report, the clinical diagnose of a patient with immune thrombocytopenic purpura and spontaneous gingival hemorrhage by a dentist is presented. The patient did not have any systemic disease that wou...

Idiopathic thrombocytopenic purpura in children usually a self limiting disorder. It may follow a viral infection or immunisation and is caused by an inappropriate response of the immune system. About 20-30% of children will fail to remit over six months (chronic idiopathic thrombocytopenic purpura). This is more likely in older children, especially girls. The disease is reviewed with reference...