results the mean age of chb patients was 38.5± 11.9 years and 55.9% of them (231 patients) were male. there were 13 cases (3.1%) with hdv infection. there was no association between positive anti-hdv serology and factors such as age, gender, carrier state, liver enzymes, and positive hepatitis b e antigen (hbeag) serology. conclusions although hdv had a low prevalence in our area, it is importa...

conclusions we introduced an anti-hbsp antibodies elisa, designed for locally circulating hbv strains. correlation observed of anti-hbsp with liver fibrosis staging regardless of viral replication and liver inflammation suggests anti-hbsp antibodies as possible indicator for hbv-associated liver fibrosis. results seven out of eighty (9%) chb patients were positive for anti-hbsp antibodies. mean...

در سالهای اخیر پیشرفتهای چشمگیری در تشخیص و درمان هپاتیت مزمن ب به دست آمده  و هر چند سال یک بار تغییر و تحولات قابل توجهی در نحوه درمان چنین بیمارانی به دنبال داشته است. اگرچه در چند سال اخیر راهنماهای درمانی متعددی برای هپاتیت مزمن ب در سطح دنیا ارائه شده است(5-1)، با گذشت زمان و انجام تحقیقات جدید، تفاوتهایی بین راهنماهای درمان قابل مشاهده می شود. علاوه بر این بسیاری از داروهای جدید قیمت بسی...

objective: chronic infection of hepatitis b and hepatitis c are considered as the most important infectious diseases, which lead to drastic consequences such as liver dysfunction. depression is a psychiatric disorder which is concomitantly present in these patients, and decreases the patients’ quality of life. it may lead to suicide, homicide or intentional transmission of infectious to others....

background occult hepatitis b virus infection (obi) is defined as the presence of hepatitis b virus (hbv) dna in the liver and/or in the serum of patients with negative results of hepatitis b s antigen (hbsag) test with or without serological markers of previous viral exposure. the impact of obi in patients with chronic hepatitis c (chc) is still unclear. objectives the aim of this study was to...

emerging new medications in the treatment of hbv produces hope and promises for curing of hbv. over the past decade, the development of oral nucleoside/nucleotide analogs (nas) with favorable potencies and tolerabilities has led to substantial advances in chronic hepatitis b (chb) therapy. the oral anti-hbv agents currently approved are lamivudine, adefovir dipivoxil , entecavir , telbivudine, ...

context the pnpla3 i148m variant has been recognized as a genetic determinant of liver fat content and a genetic risk factor of liver damage progression associated with steatohepatitis. the i148m variant is associated with many chronic liver diseases. however, its potential association with inflammatory and autoimmune liver diseases has not been established. evidence acquisition we systemically...

background: more than 350 million people are chronic carriers of hepatitis b virus (hbv) and because of the high hbv-related morbidity and mortality, the global disease burden of hbv is substantial. in patients with hbeag–negative chronic hepatitis b (chb) with serum alanine aminotransferase (alt) levels, 1-2 × upper limit of normal (uln) and hbv dna load of 10000 to 100000 copies/ml, liver bio...

 ABSTRACT Background: Hepatitis B virus (HBV) infection in patients who lack detectable hepatitis B surface antigen (HBsAg) is called occult hepatitis B infection. Such infections have been frequently identified in patients with chronic hepatitis Cliver disease, but their prevalence is not known. Methods: 207 patients with chronic hepatitis C who were HCV -RNA and antiHCV positive were stu...