background: regulatory t cells have been suggested to have a protective role against acute rejection in allograft recipients. however, there is little information available about their contribution to chronic rejection process. the role of transforming growth factor-beta 1 (tgf- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. objectives: to eva...

the introduction of ex vivo lung perfusion (evlp) in the practice of lung transplantation has allowed the reconditioning of the marginal grafts and their conversion into transplantable grafts. in addition, evlp can provide a platform for the application of various preventive measures to decrease the incidence of post-transplant complications. while the toronto team targets the attenuation of th...

OBJECTIVES Graft loss owing to chronic allograft dysfunction is a major concern in renal transplant recipients. We assessed the affect of immune and nonimmune risk factors on death-censored graft loss in renal transplant recipients with chronic allograft dysfunction. MATERIALS AND METHODS We performed a retrospective, single-center study on 214 renal transplant recipients with chronic allogra...

Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic and/or immunoregulatory cytokine in renal allografts is also controversial. Objectives: To eva...

Respiratory tract colonisation with Pseudomonas aeruginosa may represent a treatable trait to avert subsequent development of chronic lung allograft dysfunction in transplant recipientshttps://bit.ly/35rCVhW

The major causes of renal transplant loss are death from vascular, malignant or infectious disease, and loss of the allograft from chronic renal dysfunction associated with the development of graft fibrosis and glomerulosclerosis. Chronic allograft nephropathy (CAN) is the histologic description of the fibrosis, vascular and glomerular damage occurring in renal allografts. Clinical programs rel...