نتایج جستجو برای: chromosomal damage
تعداد نتایج: 270697 فیلتر نتایج به سال:
due to importance of combination therapies in cancer treatment, this study was performed to find the effects of hyperthermia and neutron irradiation and heir combination on the human lymphocytes. blood samples were treated separately with 41.5 °c for 30 and 60 minutes, 43 °c for 15 and 30 minutes, as well as 10 cgy neutron irradiation. they also treated with hyperthermia followed by irradiation...
background: this study has used biomarker of exposure-effect continuum to examine the biological characteristics of organophosphate (op) toxicity and its genotoxic effect among rice farmers. materials and methods : a cross-sectional study was conducted among 160 pesticide exposed rice farmers and 160 adults from the fishing village as the unexposed group. they share the common socio-economica...
Background: Sperm chromatin insufficiencies leading to low sperm count and quality, infertility and transmission of chromosomal microdeletion and aneuploidies to next generations can be due to exposure to environmental pollutions, chemicals and natural or manmade ionizing radiation. In this project which has continued for more than 10 years and is unique in many technical aspects in Iran and in...
Introduction: Exposure to ionizing radiation as a result of diagnostic, treatment and occupational reasons, has created a remarkable range of cytogenetic damage in the DNA, as the first and main goal of ionizing radiation. The aim of this study is to assess the chromosomal damage in medical radiotherapy workers and its association with effective parameters such as age, sex, duration of employme...
background: synthetic radio-protective agents like aminothiols are toxic and fda approved agent amifostine is no exception. some ayurvedic herbs have shown radioprotective potential. this study was carried out to test and compare the radioprotective potential of curcuma longa (cl) tinospora cordifolia (tc), zizyphus mauritiana (zm) and ocimum sanctum (os) against 2gy gamma irradiation in swiss ...
Investigation of 44 paired test and control patients, all suffering from rheumatoid arthritis, following exposure to phenylbutazone (PBZ) and/or oxyphenbutazone (OPB), suggests that there is no significant increase in the level of chromosomal damage in lymphocytes. The control subjects comprised two series, one previously exposed to PBZ and/or OPB, but not for at least 1-5 years, and the other ...
Background: Nonlethal genetic damage is the basis for carcinogenesis. As various gene aberrations accumulate, malignant tumors are formed, regardless of whether the genetic damage is subtle or large enough to be distinguished in a karyotype. The study of chromosomal changes in tumor cells is important in the identification of oncogenes and tumor suppressor genes by molecular cloning of genes in...
background: various frequencies of sperm aneuploidy are reported in sperms of subfertile patients compared to normal individuals. moreover, sperm dna damage is shown to be associated with male infertility. in this study, the rate of dna damage and frequencies of aneuploidy in sperms of subfertile patients was investigated. methods: semen samples were obtained from healthy normal and subfertile ...
Background: Various frequencies of sperm aneuploidy are reported in sperms of subfertile patients compared to normal individuals. Moreover, sperm DNA damage is shown to be associated with male infertility. In this study, the rate of DNA damage and frequencies of aneuploidy in sperms of subfertile patients was investigated. Methods: Semen samples were obtained from healthy normal and subfertile ...
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