نتایج جستجو برای: chromosomal aberrations
تعداد نتایج: 57831 فیلتر نتایج به سال:
Background: Nonlethal genetic damage is the basis for carcinogenesis. As various gene aberrations accumulate, malignant tumors are formed, regardless of whether the genetic damage is subtle or large enough to be distinguished in a karyotype. The study of chromosomal changes in tumor cells is important in the identification of oncogenes and tumor suppressor genes by molecular cloning of genes in...
Background and purpose : Ït is clearly shown that ionising radiations induce various kinds of DNÂ damages majority of which as sub-lethal damages, are repaired but still some of them are left urepaired and lead to chromosomal aberrations. These chromosomal aberrations in radiation workers, who are occupationally exposed to radiation,could be assayed with cytogenetic evaluation methods.These c...
objective: chromosomal aberrations are common causes of multiple anomaly syndromes. recurrent chromosomal aberrations have been identified by conventional cytogenetic methods used widely as one of the most important clinical diagnostic techniques. materials and methods: in this retrospective study, the incidences of chromosomal aberrations were evaluated in a six year period from 2005 to 2011 i...
background: genome instability is a main cause of chromosomal alterations in both somatic and germ cells when exposed to environmental, physical and chemical genotoxicants. germ cells especially spermatozoa are more vulnerable to suffering from dna damaging agents during spermatogenesis and also more potent in transmitting genome instability to next generation. methods: to investigate the effec...
an experimental study was accomplished to compare estimation methods of ionizing radiations genotoxicity in mammalian cell cultures by means of two cytogenetic parameters with focus on aberrant cells characterized by multiple chromosomal damages.in vitro study was carried out on the genotoxicity of low-medium doses of 190 kv x-rays absorbed in chinese hamster ovary cell cultures. micronuclei an...
Background: Rapidly increasing possibilities of exposure to environmental extremely low-frequency electromagnetic fields (ELF-EMF) have become a topic of worldwide investigation. Epidemiological and laboratory studies suggest that exposure to ELF-EMF may increase cancer risk therefore assessment of chromosomal damage in various cell lines might be of predictive value for future risk es...
Background and Objective: Hybrid cells are made from fusion of two or more somatic cells. After formation chromosomes are located in one membrane . . So nucleic condition of each fused cell has changes and two genomes and chromosomes interact with each other. Locating the genes in new nucleic and cytoplasmic condition and great chromosomal rearrangement in these new formed cells can affect th...
Background: Chromosomal aberrations can be one of the causes of fertility problems, including infertility or frequent abortions. Identification of chromosomal aberrations by clinical diagnostic techniques has been primarily performed through standard karyotyping. In this screening, the prevalence of these disorders were checking in individuals with fertility problems from west population of Ira...
Background: Cirrhinus mrigala, one of the important fish widely consumed in India, was used for karyological observations and to evaluate the toxic effect of butachlor, an extensively used herbicide in rice fields in terms of chromosomal aberration test. Methods: Fishes were collected from “National Fish Seed Farm” Jyotisar with mean body weight of 20-50g. The experimental fishes were kept i...
background: rapidly increasing possibilities of exposure to environmental extremely low-frequency electromagnetic fields (elf-emf) have become a topic of worldwide investigation. epidemiological and laboratory studies suggest that exposure to elf-emf may increase cancer risk therefore assessment of chromosomal damage in various cell lines might be of predictive value for future risk estimation....
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