نتایج جستجو برای: chop

تعداد نتایج: 4508  

A. Moise A. Romairone Duarte D. Jones J. A. Montoya-Alonso J. C. Cartagena Albertus, J. Engel Manchado S. Moya Garcia

The aims of this retrospective study were to evaluate the efficacy of different steroid formulations (depot vs oral) and if the continuous administration of steroids throughout and beyond a CHOP protocol might improve the survival time and rate of cats with mediastinal lymphoma. The medical records of client-owned cats diagnosed with mediastinal lymphoma were reviewed at two veterinary referral...

Journal: :Blood 2004
Michael Pfreundschuh Lorenz Trümper Marita Kloess Rudolf Schmits Alfred C Feller Christian Rübe Christian Rudolph Marcel Reiser Dieter K Hossfeld Hartmut Eimermacher Dirk Hasenclever Norbert Schmitz Markus Loeffler

Cyclophosphamide, doxorubicin, vincristine, and prednisone, given every 3 weeks (CHOP-21), is standard chemotherapy for aggressive lymphomas. To determine whether biweekly CHOP (CHOP-14) with or without etoposide is more effective than CHOP-21, 689 patients ages 61 to 75 years were randomized to 6 cycles of CHOP-21, CHOP-14, CHOEP-21 (CHOP plus etoposide 100 mg/m2 days 1-3), or CHOEP-14. Patien...

Journal: :The Lancet. Oncology 2008
Michael Pfreundschuh Joerg Schubert Marita Ziepert Rudolf Schmits Martin Mohren Eva Lengfelder Marcel Reiser Christina Nickenig Michael Clemens Norma Peter Carsten Bokemeyer Hartmut Eimermacher Anthony Ho Martin Hoffmann Roland Mertelsmann Lorenz Trümper Leopold Balleisen Ruediger Liersch Bernd Metzner Frank Hartmann Bertram Glass Viola Poeschel Norbert Schmitz Christian Ruebe Alfred C Feller Markus Loeffler

BACKGROUND Cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) is used to treat patients with non-Hodgkin lymphoma. Interval decrease from 3 weeks of treatment (CHOP-21) to 2 weeks (CHOP-14), and addition of rituximab to CHOP-21 (R-CHOP-21) has been shown to improve outcome in elderly patients with diffuse large B-cell lymphoma (DLBCL). This randomised trial assessed whether six...

Journal: :Circulation research 2016
Xiaoyan Dai Ye Ding Zhaoyu Liu Wencheng Zhang Ming-Hui Zou

RATIONALE Elevated levels of CHOP (C/EBP homologous protein), a member of the C/EBP transcription factor family, in advanced atherosclerotic plaques is reported to be associated with atherosclerotic plaque rupture in humans. However, the molecular mechanism by which CHOP accumulation occurs is poorly defined. OBJECTIVE The aim of this study was to investigate if (1) macrophage AMPK (AMP-activ...

Journal: :The New England journal of medicine 1998
T P Miller S Dahlberg J R Cassady D J Adelstein C M Spier T M Grogan M LeBlanc S Carlin E Chase R I Fisher

BACKGROUND Patients with clinically localized, intermediate- or high-grade non-Hodgkin's lymphoma usually receive initial treatment with a doxorubicin-containing regimen such as cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). Pilot studies suggest that eight cycles of CHOP alone or three cycles of CHOP followed by involved-field radiotherapy are effective in such patients. ...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2008
Nobuyuki Tamaki Etsuro Hatano Kojiro Taura Masaharu Tada Yuzo Kodama Takashi Nitta Keiko Iwaisako Satoru Seo Akio Nakajima Iwao Ikai Shinji Uemoto

CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) is a key component in endoplasmic reticulum (ER) stress-mediated apoptosis. The goal of the study was to investigate the role of CHOP in cholestatic liver injury. Acute liver injury and liver fibrosis were assessed in wild-type (WT) and CHOP-deficient mice following bile duct ligation (BDL). In WT livers, BDL induced overexpressio...

Journal: :Circulation research 2015
Alex-Xianghua Zhou Xiaobo Wang Chyuan Sheng Lin Jaeseok Han Jing Yong Marissa J Nadolski Jan Borén Randal J Kaufman Ira Tabas

RATIONALE Myeloid-derived C/EBP-homologous protein (CHOP), an effector of the endoplasmic reticulum stress-induced unfolded protein response, promotes macrophage apoptosis in advanced atherosclerosis, but the role of CHOP in vascular smooth muscle cells (VSMCs) in atherosclerosis is not known. OBJECTIVE To investigate the role of CHOP in SM22α(+) VSMCs in atherosclerosis. METHODS AND RESULT...

2006
Marinus H. J. van Oers Richard Klasa Robert E. Marcus Max Wolf Eva Kimby Randy D. Gascoyne Andrew Jack Mars van’t Veer Andrej Vranovsky Harald Holte Martine van Glabbeke Ivana Teodorovic Cynthia Rozewicz Anton Hagenbeek

We evaluated the role of rituximab (R) both in remission induction and maintenance treatment of relapsed/resistant follicular lymphoma (FL). A total of 465 patients were randomized to induction with 6 cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) (every 3 weeks) or R-CHOP (R: 375 mg/m2 intravenously, day 1). Those in complete remission (CR) or partial remission (PR...

Journal: :Circulation 2012
Céline Loinard Yasmine Zouggari Patricia Rueda Bhama Ramkhelawon Clément Cochain José Vilar Alice Récalde Adéle Richart Dominique Charue Micheline Duriez Masataka Mori Fernando Arenzana-Seisdedos Bernard I Lévy Christophe Heymes Jean-Sébastien Silvestre

BACKGROUND C/EBP homologous protein-10 (CHOP-10) is a novel developmentally regulated nuclear protein that emerges as a critical transcriptional integrator among pathways regulating differentiation, proliferation, and survival. In the present study, we analyzed the role of CHOP-10 in postnatal neovascularization. METHODS AND RESULTS Ischemia was induced by right femoral artery ligation in wil...

Journal: :Blood 2009
Volkmar Boehme Norbert Schmitz Samira Zeynalova Markus Loeffler Michael Pfreundschuh

One thousand two hundred twenty-two patients treated in the Rituximab with CHOP over age 60 years (RICOVER-60) trial were examined for central nervous system (CNS) disease developing during first-line therapy or after a complete or partial remission had been achieved. Patients received 6 or 8 courses of CHOP (cyclophosphamide, adriamycin, vincristine, prednisone) administered every 2 weeks (CHO...

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