نتایج جستجو برای: cholesterol 24
تعداد نتایج: 429623 فیلتر نتایج به سال:
background abnormal cholesterol homeostasis is associated with the pathogenesis of neurodegenerative disease and cognitive impairment. objectives our objective was to evaluate changes in the expression of proteins related to cognition and cholesterol homeostasis in the hippocampi of rats as well as behavioral modifications following the administration of a cholesterol-rich diet. methods in this...
هدف از این مطالعه ارزیابی میزان لیپوپروتئین آ در بیماران دیابتی در مقایسه با گروه کنترل بود. همچنین یافتن ارتباط بین کنترل قند خون و چربی های خون با لیپوپروتئین ? در بیماران دیابتی و گروه کنترل. مواد و روش ها: در این مطالعه مورد شاهدی186 فرد 20 تا 70 ساله شامل 100 بیمار دیابت نوع 2 و 24 بیمار دیابت نوع 1 و 62 فرد سالم به عنوان گروه کنترل وارد مطالعه شدند. تمام بیماران دیابتی تحت کنترل قند خو...
Cytochrome P450 46A1 (cholesterol 24-hydroxylase) is an important brain enzyme that may be inhibited by structurally distinct pharmaceutical agents both in vitro and in vivo. To identify additional inhibitors of CYP46A1 among U.S. Food and Drug Administration-approved therapeutic agents, we used in silico and intuitive predictions and evaluated some of the predicted binders in the enzyme and sp...
Most cholesterol turnover takes place in the liver and involves the conversion of cholesterol into soluble and readily excreted bile acids. The synthesis of bile acids is limited to the liver, but several enzymes in the bile acid biosynthetic pathway are expressed in extra-hepatic tissues and there also may contribute to cholesterol turnover. An example of the latter type of enzyme is cholester...
Key words cholesterol 24-hydroxylase - epilepsy central nervous system
Cholesterol 24-hydroxylase (CYP46A1) is responsible for brain cholesterol elimination and therefore plays a crucial role in the control of brain cholesterol homeostasis. Altered CYP46A1 expression has been associated with several neurodegenerative diseases and changes in cognition. Since CYP46A1 activates small guanosine triphosphate-binding proteins (sGTPases), we hypothesized that CYP46A1 mig...
The brain is the most cholesterol-rich organ in the body. Brain cholesterol is characterized by a very low turnover with very little exchange with lipoproteins in the circulation. Very recently we showed that there is a continuous age-dependent flux of 24(S)-hydroxycholesterol from the human brain into the circulation (Lütjohann, D., Breuer, O., Ahlborg, G., Nennesmo, I., Sidén, A., Diczfalusy,...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید