Background: Fertility protection is important in young patients with Hodgkin's lymphoma. Objective: The goal of this study was to determine the effects of ABVD and ChlVPP chemotherapeutic protocols for Hodgkin's disease on the spermatozoa fertility indices of male rat. Materials and Methods: After determining tolerance dose of drugs in pilot study, 24 male rats were divided to four groups: ABVD...

We present feasibility, toxicity and efficacy results of an intensified six-cycle ChlVPP/ABVVP regimen in advanced Hodgkin lymphoma (HL). From February 2004 to August 2007, 82 consecutive eligible patients were enrolled. According to the Hasenclever index, 64 patients (78%) were considered at low risk, 15 (18%) at intermediate and 3 (4%) at high risk. The most relevant toxicity was haematologic...

background: fertility protection is important in young patients with hodgkin's lymphoma. objective: the goal of this study was to determine the effects of abvd and chlvpp chemotherapeutic protocols for hodgkin's disease on the spermatozoa fertility indices of male rat. materials and methods: after determining tolerance dose of drugs in pilot study, 24 male rats were divided to four groups: abvd...

Davide Degli Esposti1,2, Morando Soffritti3,*, Antoinette Lemoine1,2, Eva Tibaldi3 and Marco Manservigi3 1AP-HP, Hôpital Paul Brousse, Service de Biochimie et Biologie Moléculaire, Inserm; Université Paris-Sud 11; PRES Universud-Paris; Paul Vaillant Couturier 2Laboratoire de Biochimie et Biologie Cellulaire, Faculté de Pharmacie, Université Paris-Sud 11, Jean Baptiste Clément 3Cesare Maltoni Ca...

-Since 1975, 191 patients with Hodgkin's disease have been treated with a combination of chlorambucil, vinblastine, procarbazine and prednisolone (ChlVPP). Complete remission rates were 73% for previously untreated patients, 910% for patients previously treated with radiotherapy and 55%0 for patients previously treated with chemotherapy. In 59 patients with advanced disease who received no othe...

Advanced-stage Hodgkin lymphoma (HL) usually includes all patients diagnosed in Ann Arbor stages III and IV. Many groups also include patients with stage IIB and additional risk factors such as large mediastinal mass and/or extranodal disease. Historically, less than 5% of these patients survived when left untreated or received singleagent chemotherapy. With the development of multi-agent chemo...

Irene Latorre ([email protected]) Xavier Martinez Lacasa ([email protected]) Roser Font ([email protected]) Alicia Lacoma ([email protected]) Jordi Puig ([email protected]) Cristina Tural ([email protected]) Josep Lite ([email protected]) Cristina Prat ([email protected]) Eva Cuchi ([email protected]) Vicente Ausina ([email protected]) Jose Dominguez (jadomb@gmail....

1 Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America, 2 The Chagas Disease Foundation, Bogart, Georgia, United States of America, 3 Laboratory of Eco-Epidemiology, Department of Ecology, Genetics and Evolution, Universidad de Buenos Aires, Buenos Aires, Argentina, 4 Venezuelan Institute for Scientific Research, Caracas, Venezuela, ...

Eva Bjerre Ostenfeld1,2 Trine Frøslev1 Søren Friis3 Per Gandrup2 Mogens Rørbæk Madsen4 Mette Søgaard1,5 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of Surgery A, Aarhus University Hospital, Aalborg, Denmark; 3Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark; 4Department of Surgery A, Herning Regional Hospital, H...