Chlorothiazide sodium for injection, USP is a sterile lyophilized white powder and is supplied in a vial containing: Chlorothiazide sodium equivalent to chlorothiazide 500 mg, and the inactive ingredient mannitol 250 mg with sodium hydroxide to adjust pH. Chlorothiazide is a diuretic and antihypertensive. It is 6-chloro-2H-1,2,4-benzothiadiazine-7sulfonamide 1,1-dioxide, and its structural form...

The acute effects of intravenous (i.v.) probenecid and chlorothiazide on renal urate handling were investigated in paired studies in normal men. Uricosuric responses to these agents were compared in the same subjects, both without and with pyrazinamide (PZA) pretreatment. Assuming that PZA selectively inhibits the tubular secretion of urate and that uricosuric agents act by increasing the excre...

The administration of chlorothiazide both to man and to rats results in hyperglycemia following a glucose load. Its administration to rats causes a decreased rate of glucose utilization by their adipose tissue in vitro. Chlorothiazide added directly to the incubating medium also decreases the rate of glucose utilization of rat adipose tissue. These effects of chlorothiazide are most likely due ...

Chlorothiazide (CTZ), unlike other thiazide diuretics, can form salts. An injectable formulation containing the sodium salt is available; however neither the physicochemical characteristics of the salt nor its solid state form have been previously reported. This work reports on the crystal structure of chlorothiazide sodium. The structure was investigated by single crystal X-ray and nuclear mag...

j 1 demonstrated the potentiation of antihypertensive agents by chlorothiazide,1-3 its value alone in patients with moderately severe and severe hypertension has not been established. This investigation was designed to compare the effectiveness of alternate 6-month courses of chlorothiazide alone with standard antihypertensive therapy, and to compare the results of these periods with those of a...

The saluretic effect of the thiazide diuretics has been attributed to inhibition of sodium reabsorption in the distal nephron of the kidney. Recent micropuncture studies have shown, however, that chlorothiazide administration can also inhibit sodium reabsorption in the proximal convolution. To clarify the site of the saluretic effect of chlorothiazide, these micropuncture studies examined the e...

The mechanism of the antihypertensive effect of chlorothiazide does not difler from that of such potent salt-depleting therapeutic agents as the mercurial diuretics and tlw rice diet. The extracellular fluid and plasma volumes are reduced and, as 44 result, right hecrrt filling pressure, cardiac output, and blood pressure (if abnormally elevated by some pressor stimu1u.y) fall. Becal4se of the ...

CHLOROTHIAZIDE, commercially available as Diuril, was introduced to the general medical profession January 1, 1958. It had been available to clinical investigators during the previous year. In this span it has won wide acceptance as an oral diuretic and antihypertensive agent. These comments should be considered in the light of this relatively brief experience. The chemical structure of chlorot...

1 RIAMTERENE MEDICAL JOURNAL azotaemia with intermittent use of SKF 8542 suggests there is some reversible effect on renal blood-flow. The diuretic response to the combination of SKF 8542 and chlorothiazide is excellent and all patients lost their ascites. The drug was active within a few hours of administration, and, unlike spironolactone, need not be given on consecutive days to obtain a diur...