نتایج جستجو برای: chloride channel

تعداد نتایج: 305756  

Journal: :physiology and pharmacology 0
javad fahanik babaei department of physiology and neuroscience research center, shahid beheshti university of medical sciences, evin, tehran 19857, iran. afsaneh eliassi : department of physiology and neuroscience research center, shahid beheshti reza saghiri department of biochemistry, pasteur institute of iran.

introduction: recent studies have shown the presence of cl- channels in heart and liver mitochondrial membranes. in this work, we have characterized the functional profile of a cl- channel from rat brain mitochondria. methods: after removing and homogenizing the rat brain, the supernatant was separately centrifuged in msedigitonin, h2o and na2co3 and mitochondrial inner membrane vesicles were o...

Journal: :iranian journal of basic medical sciences 0
miao-miao bi department of ophthalmology, the second hospital of jilin university, jilin university, changchun, jilin, 130041, p.r. china department of ophthalmology, the china-japan :union: hospitial of jilin university, jilin university, changchun, jilin, 130033, xiantai street no. 126, jilin province, china sen hong department of colon and anal surgery, the first hospital of jilin university, jilin university, changchun, jilin, 130021, p.r. china ling-jun ma department of ophthalmology, the china-japan :union: hospitial of jilin university, jilin university, changchun, jilin, 130033, xiantai street no. 126, jilin province, china hong-yan zhou department of ophthalmology, the china-japan :union: hospitial of jilin university, jilin university, changchun, jilin, 130033, xiantai street no. 126, jilin province, china jia lu department of ophthalmology, the china-japan :union: hospitial of jilin university, jilin university, changchun, jilin, 130033, xiantai street no. 126, jilin province, china

objective(s): the purpose of this study was to investigate the role of chloride channel protein 2 (clc-2) in glutamate-induced apoptosis in the retinal ganglion cell line (rgc-5). materials and methods: rgc-5 cells were treated with 1 mm glutamate for 24 hr. the expression of clc-2, bax, and bcl-2 was detected by western blot analysis. cell survival and apoptosis were measured by 3-(4,5-dimethy...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Mirko Moroni Istvan Biro Michele Giugliano Ranjit Vijayan Philip C Biggin Marco Beato Lucia G Sivilotti

In the vertebrate CNS, fast synaptic inhibition is mediated by GABA and glycine receptors. We recently reported that the time course of these synaptic currents is slower when intracellular chloride is high. Here we extend these findings to measure the effects of both extracellular and intracellular chloride on the deactivation of glycine and GABA currents at both negative and positive holding p...

Journal: :American journal of physiology. Cell physiology 2012
Liwei Wang Wenbo Ma Linyan Zhu Dong Ye Yuan Li Shanwen Liu Huarong Li Wanhong Zuo Bingxue Li Wencai Ye Lixin Chen

Acid-activated chloride currents have been reported in several cell types and may play important roles in regulation of cell function. However, the molecular identities of the channels that mediate the currents are not defined. In this study, activation of the acid-induced chloride current and the possible candidates of the acid-activated chloride channel were investigated in human nasopharynge...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2012

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