نتایج جستجو برای: chlorambucil
تعداد نتایج: 2068 فیلتر نتایج به سال:
1. dept. of hematology and medical oncology, kermanshah university of medical sciences, kermanshah, iran 2. students research committee, kermanshah university of medical sciences, kermanshah, iran 3. medical biology research center, kermanshah university of medical sciences, kermanshah, iran corresponding author: masoud sadeghi, msc. tel: (+98) 9185960644 ema...
The study compared chlorambucil alone with chlorambucil in combination with plasma exchange in patients with polyneuropathy associated with monoclonal IgM. Forty four patients were prospectively randomly assigned, in a comparative open trial, to receive either 0.1 mg/kg/day chlorambucil orally, for 12 months or chlorambucil associated with 15 courses of plasma exchange, during the first four mo...
Conjugate of podophyllotoxin with chlorambucil: synthesis, biological testing and molecular modeling
In the present work we have studied a novel conjugate of DNA alkylating agent chlorambucil with podophyllotoxin, ligand colchicine binding site in tubulin. The target compound was obtained by Steglich esterification podophyllotoxin percentage yield 41%. Results biotesting carried out on carcinoma A549 cell line revealed that at concentration 2 μM caused full depolymerization microtubules withou...
BACKGROUND The monoclonal anti-CD20 antibody rituximab, combined with chemotherapeutic agents, has been shown to prolong overall survival in physically fit patients with previously untreated chronic lymphocytic leukemia (CLL) but not in those with coexisting conditions. We investigated the benefit of the type 2, glycoengineered antibody obinutuzumab (also known as GA101) as compared with that o...
MABLE investigated the efficacy and safety of rituximab plus bendamustine or rituximab plus chlorambucil in fludarabine-ineligible patients with chronic lymphocytic leukemia. Patients received rituximab plus bendamustine or rituximab plus chlorambucil every four weeks for six cycles. Rituximab plus chlorambucil-treated patients without a complete response after Cycle 6 received chlorambucil mon...
Chemotherapeutics for the treatment of tumorigenic conditions that feature novel modes of action are highly sought after to overcome the limitations of current chemotherapies. Herein, we report the conjugation of the alkylating agent chlorambucil to the RAPTA scaffold, a well-established pharmacophore. While chlorambucil is known to alkylate DNA, the RAPTA complexes are known to coordinate to a...
BACKGROUND Chronic lymphocytic leukemia (CLL) has been the most common type of leukemia in adults worldwide, and then more common in the elderly, markedly more common in patients over the age of 65 years. METHODS Seventy patients with CLL have referred to Clinic of Hematology-Oncology, Kermanshah, Iran, between Jan 2000 and Jun 2014. We have analyzed age, sex, survival, kind of chemotherapy a...
Introduction Chronic lymphatic leukaemia is a disease of the elderly with a long natural history. Treatment is palliative, with chlorambucil the drug of choice (Livingston and Carter, 1970). The recognized side effects of chlorambucil include nausea, myelosuppression, skin eruptions and pulmonary fibrosis (Stenfert Kroese, 1975), but their incidence is low. Although high doses of chlorambucil a...
Chlorambucil (4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid) is an alkylating agent, indicated in chronic lymphocytic leukaemia. Kolaviron (KV), a biflavonoid complex from Garcinia kola, and L-ascorbic acid (AA) are known to protect against oxidative damage in vivo. This study evaluates the protective capacity of KV and AA on chlorambucil-induced oxidative stress in the testes of rat. Twen...
Many tumor cells, including murine ADJ/PC6 plasmacytoma cells, possess an active energy dependent polyamine uptake system which selectively accumulates endogenous polyamines and structurally related compounds. We have attempted to target the cytotoxic drug chlorambucil to a tumor possessing this uptake system by conjugating it to the polyamine spermidine. Furthermore, since polyamines have a hi...
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