PURPOSE To evaluate individual tumor control following chemoreduction for retinoblastoma. METHODS Prospective nonrandomized single-center case series of 457 retinoblastomas managed with six cycles of chemoreduction (vincristine, etoposide, and carboplatin). The tumors were then managed with chemoreduction alone (group A) or chemoreduction combined with thermotherapy (group B), cryotherapy (gr...

OBJECTIVE To evaluate the effectiveness of chemoreduction alone and chemoreduction with thermotherapy for macular retinoblastoma. DESIGN Prospective, nonrandomized, single-center case series. SETTING Ocular Oncology Service at Wills Eye Hospital of Thomas Jefferson University in conjunction with the Division of Oncology at the Children's Hospital of Philadelphia (Pa). PARTICIPANTS There w...

OBJECTIVE To evaluate the histopathologic findings in the eyes with retinoblastoma that had been treated only with chemoreduction. DESIGN Clinicopathologic series. Study Material Ten eyes of 8 patients with retinoblastoma that were enucleated after therapy consisting only of systemic chemotherapy (chemoreduction). METHODS All cases received a chemoreduction regimen including a combination o...

OBJECTIVE To evaluate whether neoadjuvant intravenous chemotherapy (chemoreduction) for retinoblastoma reduces the risk for associated intracranial neuroblastic tumor (trilateral retinoblastoma). DESIGN Retrospective consecutive case series. PARTICIPANTS Two hundred fourteen consecutive children with newly diagnosed retinoblastoma treated at a major ocular oncology center from January 1, 19...

BACKGROUND The purpose of this study was to evaluate the risk of metastatic disease and orbital recurrence in advanced retinoblastoma treated with systemic chemoreduction versus primary enucleation. METHODS A retrospective review of patients with Group D/E retinoblastoma was conducted with data collection from 1995 to 2015. Overall, 345 eyes (294 patients) were included (165 Group D and 180 G...

OBJECTIVE To explore the clinical efficacy and prognostic factors of chemoreduction combined with topical treatment of advanced intraocular retinoblastoma (RB). MATERIALS AND METHODS A total of 22 eyes from 17 children with RB were selected for the study and treated with chemoreduction combined with topical cryotherapy, transpupillary thermotherapy (TTT) or episcleral plaque brachytherapy. Cl...

OBJECTIVE To evaluate the change in regression pattern following chemoreduction and tumor consolidation therapy (thermotherapy or cryotherapy) for retinoblastoma METHODS Retrospective medical record analysis was completed for 557 retinoblastomas (239 eyes of 157 patients) that were treated with chemoreduction and showed regression to 1 of 5 patterns (type 0, no visible remnant; type 1, comple...

BACKGROUND Retinoblastoma is a highly malignant tumor of the eye that manifests most often in the first 3 years of life. METHODS Published articles were reviewed to evaluate the clinical features and current methods of diagnosis and to assess the trends in management. RESULTS This malignancy leads to metastatic disease and death in 50% of children worldwide but in less than 5% of children i...