background: genetic variation influences susceptibility/resistance to tuberculosis. cxcl10 is involved in t-cell migration and stimulation of natural killer cells in mycobacterium tuberculosis infection. objectives: we aimed to investigate the genetic polymorphisms in promoter of the cxcl10 gene in patients with pulmonary tuberculosis (ptb) and healthy controls, to clarify whether polymorphisms...

Background: Alopecia Areata (AA) is a non-scarring, autoimmune disorder which causes hair loss. Inflammatory reactions are involved in hair loss of the scalp and/or body. The involvement of chemokine receptors in the pathogenesis of AA is well defined among which, CXCL1 acts on neutrophils and CXCL9, CXCL10 and CXCL12 and serve as T lymphocytes recruiters. Objective: To study the serum levels o...

background: alopecia areata (aa) is a non-scarring, autoimmune disorder which causes hair loss. inflammatory reactions are involved in hair loss of the scalp and/or body. the involvement of chemokine receptors in the pathogenesis of aa is well defined among which, cxcl1 acts on neutrophils and cxcl9, cxcl10 and cxcl12 and serve as t lymphocytes recruiters. objective: to study the serum levels o...

background chemokines play important roles in immune system activation against microbial infections. objectives the current study aimed to evaluate seminal levels of cxc chemokines cxcl1, cxcl9, cxcl10 and cxcl12 in chlamydia trachomatis infected patients. materials and methods the c. trachomatis infection was determined employing polymerase chain reaction (pcr)-based methods. seminal concentra...

While CXCL10 is known as a proinflammatory chemokine that is responsible for recruiting activated lymphocytes to the liver in HCV infected patients, elevated levels of CXCL10 were surprisingly shown to be a negative prognostic marker for response to therapy Development of an assay to discriminate between native and truncated CXCL10 chemokine Serial panning of the HuCAL PLATINUM® antibody librar...

The role of C-X-C motif chemokine 10 (CXCL10), a pro-inflammatory factor, in the development of acute respiratory distress syndrome (ARDS) remains unclear. In this study, we explored the role of CXCL10 and the effect of CXCL10 neutralization in lipopolysaccharide (LPS)-induced ARDS in rats. The expression of CXCL10 and its receptor chemokine receptor 3(CXCR3) increased after LPS induction. More...

OBJECTIVE To define the chemokine profile in the CSF of patients with multiple sclerosis (MS) and compare it with three control groups; patients with benign headache (headache), non-inflammatory neurological diseases (NIND), and other inflammatory neurological diseases (IND). In addition, the correlations of CSF chemokine concentrations with chemokine receptor expression on CSF CD4(+) T cells a...

The chemokine, CXCL10, chemotactic for NK cells, activated T cells, and dendritic cells is highly expressed during viral infections, including HSV-1. The importance of this chemokine to the control of HSV-1 infection was tested using mice deficient in CXCL10 (CXCL10(-/-)). Following corneal infection, HSV-1 viral titers were elevated in the nervous system of CXCL10(-/-) mice, which correlated w...

Chemokines are instrumental in macrophage- and T cell-dependent diseases. The chemokine CCL2 promotes kidney disease in two models of immune-mediated nephritis (MRL-Fas(lpr) mice and the nephrotoxic serum nephritis model), but evidence suggests that multiple chemokines are involved. For identification of additional therapeutic targets for immune-mediated nephritis, chemokine ligands and recepto...

Chemokines comprise a class of structurally related proteins that are involved in many aspects of leukocyte migration under basal and inflammatory conditions. In addition to the large number of genes, limited processing of these proteins by a variety of enzymes enhances the complexity of the total spectrum of chemokine variants. We have recently shown that the native chemokine CXCL10 is process...