Penicillins and cephalosporins are the most important betalactams inducing IgE-mediated reactions. The safety of administering cephalosporins to penicillin-allergic children is a particular problem, because cephalosporin allergenic determinants have not been properly identified. A study was undertaken to evaluate the frequency of anaphylactic reactions to cephalosporins and penicillins and thei...

Cephalosporins have been well known to have potent convulsant activity. We studied the mechanism of the convulsions induced by cephalosporins. Cefazolin, cephaloridine, cefpirome and cefmetazole inhibited the receptor binding of gamma-aminobutyric acid (GABA), an inhibitory transmitter in the mammalian central nervous system. As fluoroquinolones also inhibited GABA receptor binding and this inh...

the pharmacokinetics of cefpirome was investigated in buffalo calves following its single intramuscular (im) administration (10 mg). the peak plasma concentration of cefpirome at 30 min was 9.0 ± 0.5 μg.ml-1, which declined to 0.2 ± 0.1 μg.ml -1 at 24 hrs. the absorption half-life (t1/2ka) and elimination half-life (t1/2 β) were 0.19 ± 0.03 hr and 2.39 ± 0.05 hr, respectively. the area under th...

Abstract Objectives Data on cephalosporin consumption in the community were collected from 30 EU/EEA countries over two decades. This article reviews temporal trends, seasonal variation, presence of change-points and changes composition main subgroups cephalosporins. Methods For period 1997–2017, data cephalosporins (i.e. first-, second-, third- fourth-generation cephalosporins; ATC J01DB, J01D...

In this study, the effects of antimicrobial agents on 105 P.aeruginosa strains isolated from various clinical specimens were examined. The frequency as follows; pus (29), urine (28); thorat (17) and ear (13) swabs, feces (10) phlegm (8). Antibiotic susceptibility test was done through Kirby-Bauer Disc Diffusion Method. to 3rd generation cephalosporins, quinolones, carbapenems aminoglycosides fo...

Cephalosporins belong to the family of beta-lactam antibiotics. Comparing the first-discovered penicillin, cephalosporins have obvious advantages since they are more stable to penicillinase and are more effective to many penicillin-resistant strains. The incidence of adverse effects for cephalosporins is also lower than that for penicillins and other anti-infectious agents. Thus, cephalosporins...

BACKGROUND Allergy to cephalosporins has mainly been evaluated in the context of patients with confirmed penicillin allergy. The problem of studying cross-reactivity in subjects primarily sensitized to cephalosporins and potentially allergic to penicillins has not been sufficiently addressed. OBJECTIVE To evaluate the in vitro IgE response and cross-reactivity to betalactams in patients with ...