the aim of this investigation was to prepare, characterize and optimize the aceclofenac proniosomes using central composite design and carry out stability studies. three independent variables selected were molar ratio of drug to lipid (x1), surfactant loading (x2) and volume of hydration (x3). based on central composite design, 16 batches of proniosomes were prepared by slurry method and evalua...

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isoniazid (inh) was studied with regard to its electrochemical treatment on a strongly alkaline solution of a poly (3,4-ethylenedioxythiophene)-modified gold electrode, using both cyclic voltammetry and controlled potential techniques. this composite electrode exhibited 4-fold higher oxidation of inh, in accordance with peak densities, than the bare gold electrode. it was used the central compo...

bioleaching of spent refinery processing catalysts using adapted indigenous strains ofacidithiobacillus ferrooxidans to recover ni and mo, and the separation of ni from bioleaching liquor usingiron magnetic nanoparticles were optimized in this study. bioleaching optimization was performed usingcentral composite design (ccd) method to optimize temperature (32 to 38oc), initial ph (1.5 to 2), par...

the aim of this work was to develop a new and simple coacervative extraction method for the preconcentration and spectrophotometric determination of cu(ii) in water samples. dithizone was used as the chelating agent while an anionic surfactant, namely sodium dodecyl sulfate (sds), was used as extracting agent at room temperature. central composite design (ccd) based on response surface methodol...

the effect of the operating conditions (temperature, time, ph, enzyme level and pulp consistency) used in the enzymatic step of a xp (cartazyme-hydrogen peroxide) sequence for bleaching kraft pulp from bagasse on various properties of the resulting pulp and paper sheet products was studied. the quality of bagasse used, was examined by its yield, brightness,viscosity and the kappa number. finall...

poly(vinylidene fluoride) (pvdf) nanofibers were prepared via electrospinning process. several different factors influence on this process and application of experimental design for its optimization is of great importance. the central composite design (ccd) was used for planning and optimizing of the experiments and also, the analysis of variance (anova) was employed for the statistical validat...

ultrasound-assisted extraction was used to determine the optimum processing conditions and to achieve the maximum extraction yield and viscosity of the gum extracted from quince seed. using response surface methodology (rsm) to design the experiments and adopting the central composite rotatable design (ccrd), the effect of extraction temperature (25-55°c), time (3-10 minutes), and ph (6-8) were...

the current study is an attempt to contribute for efficient and cost-effective substrates for xanthan gum production. in this context, the sugar cane molasses wastes can be used as a cheap substrate for xanthan gum production. xanthan biopolymer production by a novel xanthomonas campestris strain ibrc-m 10644 was optimized with statistical approaches. based on the results of response surface me...