objective: the aim of this study was to estimate the cheminformatics and qualitative structure-activity relationship (qsar) of cinnamaldehyde and eugenol. the effects of cinnamaldehyde and eugenol on the viability, doubling time and adipogenic or osteogenic differentiations of human adipose-derived mesenchymal stem cells (hascs) were also investigated.  materials and methods: qsar and toxicity ...

background: zinc has significant effects on structural and functional activities of many proteins and enzymes involved in biological activities, especially the regulation of immune-system. symptoms of zinc toxicity include nausea/vomiting, fever, cough, diarrhea, fatigue, neuropathy, and dehydration. further signs include growth retardation, altered iron function, anemia, copper deficiency, dec...

background: the anticancer agent imatinib (im) is a small molecular analog ofatp that inhibits tyrosine kinase activity of platelet derived growth factors (pdgfs)and stem cell factor (scf) receptor in cancer cells. however these factors have a keyrole in regulating growth and development of normal sertoli, leydig and germcells.objective: the aim of this study was to determine cell viability, pd...

objective: breast cancer is one of the leading causes of death in women worldwide. conventional treatments use cytotoxic drugs which have high numbers of side effects. currently pharmacologists are searching for novel drugs with fewer side effects and maximum efficiency as breast cancer treatment. the aim of the current study is to clarify the cytotoxicity effect of the recombinant outer membra...

background: astronauts will be exposed to both chronic space radiation and acute high doses of energetic radiation of solar particle events in long-term deep space missions. the application of radioprotectors in space missions has basic limitations such as their very short time window as well as their acute toxicity and considerable side effects. the aim of the present study was to investigate ...

background: ß-carbolines, harmaline and harmine, are the major alkaloids presenting in the seeds of the peganum harmala l. these alkaloids are known as herbal active principals with potential use in pharmaceutical and medicine. objectives: to assess the growth inhibitory effect of phyto-alkaloids, harmaline and harmine, on cancer cell lines. methods: the p. harmala l.’s alkaloids were extracted...

parthenolide is major sesquiterpene lactones present in anthemis haussknechtii boiss. & reut. (feverfew). this compound has many effects on different disease such as migrain and cancer. parthenolide was reported from tanacetum parthenium (l.) sch.bip. but other plants of asteraceae family could contain parthenolide. in this study parthenolide was extracted and identified with two methods, fouri...

nano-silver (agnp) has biological properties which are significant for consumer products, food technology, textiles and medical applications (e.g. wound care products, implantable medical devices, in diagnosis, drug delivery, and imaging). for their antibacterial activity, silver nanoparticles are largely used in various commercially available products. thus, the use of nano-silver is becoming ...

objective: thymoquinone (tq), as the main component of nigella sativa plant, shows anticancer properties. this study was aimed to evaluate the combined effect of tq and tamoxifen (tam) on viability and apoptosis of human breast cancer cell lines. materials and methods: in this experimental study, estrogen positive mcf-7 and estrogen negative mda-mb-231 human breast cancer cell lines were induce...

Background:  Cell viability is an important factor in radiation therapy and thus is a method to quantify the effect of the therapy. Materials and Methods: The viability of human hepatoma (HepG2) cells exposed to radiation was evaluated by both the MTT and Trypan blue assays. The cells were seeded on 96 well-plates at a density of 1 x 104 cells/well, incubated overnight, and irradiated with...