objective: the study of physiological changes in recombinant cell lines provides useful information to improve production performance. in this study, we investigate the effects of an anti-cd33 chimeric igg4 expression on sp2.0 cell growth. methods: variable region genes of light and heavy chains of monoclonal antibody produced by m195 were cloned in pfuse-clig-hk and pfuse-chig-hg4 expression ...

background: new blood vessels formation is a critical step in tumor progression. vascular density affects the clinical outcome and prognosis of malignant tumors. the aim of this study was to investigate the relation between the vascular endothelial growth factor (vegf) expression and vascular density with the clinical and histopathologic features in oral squamous cell carcinoma (oscc).   method...

purpose : to compare central corneal thickness (cct), corneal endothelial cell density, and lens capsule thickness in normotensive patients with and without pseudoexfoliation syndrome (pxs) methods : this was a prospective, comparative, descriptive study. normotensive candidates for cataract surgery with (study group) and without (control group) pxs were enrolled in the study. cct and corneal e...

the effect of shear rate on dissolution of carbon dioxide in viscoelastic wheat flour matrix and cell density in a glass barrel twin screw extruder is investigated. it is found that by increasing the shear rate there will be a decrease in the required thermodynamic conditions and hence, it improves blowing agent dissolution and increases the cell density. shear rate breaks up big bubbles and he...

this paper reviews recent strategies used for increasing specific yield and productivity in high cell density cultures. high cell density cultures offer an efficient means for the economical production of recombinant proteins. however, there are still some challenges associated with high cell density cultivation (hcdc) techniques. a variety of strategies in several aspects including host design...

microalgal growth curve, after the exponential phase, shows a stationary phase where algalbiomass production is inhibited and remains constant by some factors such as nutrientdepletion and intrinsic behavior. the present study is concerned with evaluating effects ofthe culture medium condition and intrinsic behavior on biomass production by dunaliellatertiolecta. to this end, effect of ph, nutr...

This paper reviews recent strategies used for increasing specific yield and productivity in high cell density cultures. High cell density cultures offer an efficient means for the economical production of recombinant proteins. However, there are still some challenges associated with high cell density cultivation (HCDC) techniques. A variety of strategies in several aspects including host design...

modeling the heat and mass transport in micro channel is being used extensively in researches and industrial applications. the aim is optimizing fuel cell designs before building a prototype for engineering application. in this study, numerical, three-dimensional, single phase computational fluid dynamics model of a proton exchange membrane fuel cell with both the gas distribution flow channels...

electromagnetic radiation emitted by cell-phones is a new health hazard, especially when they are used inside closed metal bodies such as cars, elevators etc. the modern wireless devices like bluetooth further enhance the effect of this radiation. the present studies were taken to get quantitative information about the actual power density levels to which a human brain is exposed inside a vehic...

Nanocomposites containing poly(methyl methacrylate) (PMMA) and surface functionalized Multi-Walled Carbon Nanotubes (MWNTs) were synthesized. The dispersion of MWNTs in PMMA was characterized using Transmission Electron Microscopy (TEM).The synthesized nanocomposites were successfully foamed using a simple method based on the in-situ generation of supercritical carbon dioxide (CO2</sub...