mesenchymal stem cells (mscs),as the major stem cells for cell therapy, have been studied from different aspects in pre-clinical and clinical settings for more than a decade. these cells modulate the immune system (humoral and cellular immune responses) in vitro by producing soluble factors (anti-inflammatory molecules) and/or making cell-cell contacts. hence they could be used in regenerative ...

conclusions although the aforementioned challenges must still be addressed, the potential of wjmscs in skin regenerative clinical treatments is promising. results similar to bone marrow mscs, wjmscs express major histocompatibility complex (mhc) class i molecules. evidence acquisition according to research conducted by various researchers, wharton’s jelly mesenchymal stem cells (wjmscs) have se...

objectives:  the efficacy of adding platelet-rich plasma (prp) to demineralized freeze-dried bone allograft (dfdba) in order to improve the clinical and radiographic results obtained in treatment of deep periodontal intrabony defects has yet to be fully elucidated. materials ­and methods: this double blind, split-mouth randomized controlled clinical trial was conducted on 12 patients with two c...

the clinical potentials of stem cells in cell-based therapies have raised great hopes in diabetes mellitus as well. however, there are complex ethical, legal, and socio-cultural issues surrounding the subject. in this paper, we intend to review in brief the main ethical issues for endocrinologists and other clinicians who are interested and work in the field of cell therapy and research.

epilepsy as one of the most common neurological disorders affects more than 50 million people worldwide with a higher prevalence rate in low-income countries. excessive electrical discharges in neurons following neural cell damage or loss cause recurrent seizures. one of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (tle) which results from hippocampal scler...

Cell therapy is a modern approach in the treatment of most of the diseases which uses stem cells and it has been recently developed rapidly. Cell therapy has shown satisfactory results in this way. Our country, Iran, has played an important role in the development of this new method and the results of stem cell treatment used for the most of the diseases were successful. The results have led to...

cell therapy is a modern approach in the treatment of most of the diseases which uses stem cells and it has been recently developed rapidly. cell therapy has shown satisfactory results in this way. our country, iran, has played an important role in the development of this new method and the results of stem cell treatment used for the most of the diseases were successful. the results have led to...

objective(s): bone marrow-derived mesenchymal stem cells (bm-mscs) potentials make them appropriate for cell therapy including ability of differentiation and release of anti-inflammatory cytokines and growth factors secreta. for treatment of azoospermia to induce proliferation and differentiation of germ cells, mscs transplantation has been introduced. the aim of the present experimental case-c...

spinal cord injury (sci) is a devastating condition, with sudden loss of sensory, motor, and autonomic function distal to the level of trauma. the primary mechanical trauma causes necrosis, edema, hemorrhage, and vasospasm. a cascade of secondary pathophysiological mechanisms is induced, including ischemia, apoptosis, fluid and electrolyte disturbances, excitotoxicity, lipid peroxidation, produ...