conclusions these results showed enhanced muscle atrophy processes following peripheral nerve damage and might provide a useful approach to study underlying muscle mechanisms associated with clinical neuropathic pain syndromes. results compared to control animals, l5 ligated animals developed mechanical and heat hypersensitivity during total period of study. soleus muscle weight as well as cdk5...

Two members of the CDK5 and ABL enzyme substrate (CABLES) family, CABLES1 CABLES2, share a highly homologous C-terminus. They interact associate with cyclin-dependent kinase 3 (CDK3), CDK5, c-ABL. mediates tumor suppression, regulates cell proliferation, prevents protein degradation. Although Cables2 is ubiquitously expressed in adult mouse tissues at RNA level, role CABLES2 vivo remains unknow...

PURPOSE To evaluate the nature of cyclin-dependent kinase 5 (CDK5) hyperactivity in pancreatic cancer progression. EXPERIMENTAL DESIGN We used genetic, biochemical, and molecular biology methods to investigate the nature and function of overexpression of CDK5 and its activators p35 and p39 during the progression of pancreatic cancer. RESULTS Amplification of the CDK5 gene or either of its m...

The potential contribution of cyclin-dependent protein kinase 5 (cdk5) to hyperphosphorylate protein tau, as claimed in Alzheimer's disease, was investigated in vivo. We generated single, double, and triple transgenic mice that coexpress human cdk5 and its activator p35 as well as human protein tau in cerebral neurons. Whereas expression and increased cdk5-kinase activity was obtained, as measu...

Cyclin-dependent protein kinase 5 (cdk5), a member of the cdk family, is active mainly in postmitotic cells and plays important roles in neuronal development and migration, neurite outgrowth, and synaptic transmission. In this study we investigated the relationship between cdk5 activity and regulation of the mitogen-activated protein (MAP) kinase pathway. We report that cdk5 phosphorylates the ...

CDK5 kinase is activated through interactions with different partners including the p35/p25 regulators. Active plays a key role in several neuronal functions and its hyperactivity contributes to variety of neurodegenerative processes human cancers, particular glioblastomas neuroblastomas. In order probe that interact CDK5, we designed synthesized fluorescent quinolimide-labelled peptides derive...

Cyclin-dependent kinase 5 (Cdk5) is a unique member of the Cdk family; its kinase activity requires association with its activator, p35 or p39. p35 is the strongest and best characterized activator. Previous studies showed that p35 is a neuron-specific protein that restricts Cdk5 activity in neurons. However, a high expression level of Cdk5 is found in astrocytes, which raises the possibility t...

Protein phosphorylation is the most common post-translational modification that regulates several pivotal functions in cells. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly active in the nervous system. It regulates several biological processes such as neuronal migration, cytoskeletal dynamics, axonal guidance and synaptic plasticity among others....