BACKGROUND AND PURPOSE Enhanced platelet activity has previously been reported in the acute phase after ischemic stroke. We tested the hypothesis that activated platelets (expressed by CD62p) are substantially increased in the acute stage after a stroke and decrease thereafter, and that antiplatelet therapies can suppress CD62p expression. METHODS We serially examined platelet CD62p expressio...

BACKGROUND Hepatic impairment, portal hypertension, and multi-systemic damage could occur during liver cirrhosis's late stage. Bleeding is a complication of hepatic cirrhosis along with several changes including blood platelet count (BPC), mean platelet volume (MPV), platelet crit (PCT) and expression of platelet CD62P. Blood platelet count (BPC), mean platelet volume (MPV), platelet distributi...

Leukocyte recruitment to sites of inflammation requires the functions of selectins and integrins. P-selectin null (CD62P-/-) mice show a mild and CD18 null (CD18-/-) mice a more severe neutrophil recruitment defect in some inflammatory models. To investigate the possible cooperative interactions between CD18 integrins and P-selectin in mediating neutrophil recruitment, we generated CD18-/-CD62P...

Standard flow cytometers provide relative numbers of activated platelets, microparticles, and platelet aggregates. With fluorescent beads it is now possible to determine absolute numbers. Whole blood and platelet-rich plasma were incubated with agonists (ADP, collagen, thrombin). CD62p expression, microparticle and platelet aggregate formation were measured. Flow-Count Fluorospheres((R)) were a...

BACKGROUND AND PURPOSE The aim of this study was to evaluate the time course of platelet activation after ischemic stroke and to investigate whether platelet activation and inflammation are correlated with each other. METHODS We serially determined expression of p-selectin (CD62p) and lysosome-associated membrane protein (CD63) by platelets using flow cytometry at 10 time points between days ...

BACKGROUND Current studies on CD62P have focused mainly on cardiovascular diseases, while only few studies have evaluated the effects of CD62P on the development of sepsis and the association between endothelial cell injury with inflammation and coagulation. This study attended to explore the association between endothelial cell injury with inflammation and coagulation by evaluating the express...

Background: Several studies reported the role platelet activation, volume (MPV) and other Indices in breast cancer but data is inconsistent and/or diverse. The aim of this study was to systematically evaluate activation indices women with BC as predictors for progression poor prognosis. Methods: Patients were recruited from our local oncology center between 2019 2020 following ethics approval. ...

Introduction: Analysis of platelet function, acetylsalicylic acid (ASA) and clopidogrel resistance in patients with peripheral arterial disease (PAD) undergoing percutaneous transluminal angioplasty (PTA), the impact procedure on this phenomenon, connection diabetes, hypertension, smoking. Material methods: The study included 72 patients, a group taking ASA permanent basis whom treatment was im...

BACKGROUND A limitation in platelet study has been the availability of platelet function-specific membrane receptor antibodies for use in the various animal species that are currently used in the study of hemostasis and other phenomena. METHODS Platelets were isolated from human and porcine blood. Resting and activated platelets were incubated with antibodies against the human cell surface re...