Background: Pattern recognition receptors (PRRs) are the main sensors of pathogen and danger signals in innate immunity of which Toll Like Receptors (TLRs) are the most studied ones. The contribution of PRRs in cerebral inflammation induced by microbial infection, tissue damage and cancer has not extensively been addressed so far. Glioma is the most common tumor of the central nervous system an...

Introduction: Allergic Rhinitis (AR) is a common inflammatory disease of the nasal mucosa. The CD14 is a receptor for lipopolysaccharide and inhaled endotoxin which can stimulate the production of interleukins by antigen presenting cells. Accordingly, CD14 plays an important role in allergic and atopic diseases, which can be one of the etiological factors for allergic diseases. The present stud...

Toll like receptors (TLRs) with a myeloid differentiation antigen (CD14) recognize and bind various structures from invading microbes and then trigger cell activation. They initiate a variety of effectors' functions, including cytokine secretion, proliferation, co-stimulation or phagocyte maturation. The aim of this study was to evaluate Toll-like receptor 4 (TLR4) and CD14 expression in childr...

Objective. To assess the presence of specific markers in patients with thymus-independent and thymus-dependent myasthenia gravis for choosing treatment tactics. Methods. The was assessed 138 (M - without thymus changes) (MH hyperplasia, MT thymoma). method ELISA (the content antibodies to subunits 1 7 nAChR blood serum, subunit thymocyte mitochondria, a detectablelevel antinuclear antibody(ANA)...

background: pattern recognition receptors (prrs) are the main sensors of pathogen and danger signals in innate immunity of which toll like receptors (tlrs) are the most studied ones. the contribution of prrs in cerebral inflammation induced by microbial infection, tissue damage and cancer has not extensively been addressed so far. glioma is the most common tumor of the central nervous system an...

background: the innate immunity plays an important role in the host response to transplantation by toll-like receptors and results in development of acute allograft rejection. the aim of this study was to evaluate the association of tlr2 and cd14 (co-receptor) gene polymorphisms with acute rejection in kidney transplant recipients.   methods : the study was conducted in a population of 239 subj...

Staining with CD14 and CD16 monoclonal antibodies will identify two monocyte subpopulations in human blood: a major population of regular monocytes, which strongly expresses the CD14 antigen (CD14++), and a minor population with weak expression of CD14 and expression of the CD16 antigen (CD14+/CD16+ cells). As shown herein, the latter cells account for 45 +/- 22 cells/microL and 9% +/- 5% of th...