نتایج جستجو برای: ccl17

تعداد نتایج: 455  

Journal: :The Journal of clinical investigation 2011
Christian Weber Svenja Meiler Yvonne Döring Miriam Koch Maik Drechsler Remco T A Megens Zuzanna Rowinska Kiril Bidzhekov Caroline Fecher Eliana Ribechini Marc A M J van Zandvoort Christoph J Binder Ivett Jelinek Mihail Hristov Louis Boon Steffen Jung Thomas Korn Manfred B Lutz Irmgard Förster Martin Zenke Thomas Hieronymus Tobias Junt Alma Zernecke

Immune mechanisms are known to control the pathogenesis of atherosclerosis. However, the exact role of DCs, which are essential for priming of immune responses, remains elusive. We have shown here that the DC-derived chemokine CCL17 is present in advanced human and mouse atherosclerosis and that CCL17+ DCs accumulate in atherosclerotic lesions. In atherosclerosis-prone mice, Ccl17 deficiency en...

2013
Yasunari Miyazaki Koji Unoura Tomoya Tateishi Takumi Akashi Tamiko Takemura Makoto Tomita Naohiko Inase Yasuyuki Yoshizawa

BACKGROUND Recent research has suggested that the Th1 and Th2 chemokine/cytokine axis contributes to the development of chronic hypersensitivity pneumonitis (HP). Acute exacerbations (AE) are significant factors in the prognosis of chronic HP. Little is known, however, about these biomarkers in association with AE in chronic HP patients. METHODS Fifty-six patients with chronic HP were evaluat...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Susanne Stutte Thomas Quast Nancy Gerbitzki Terhi Savinko Nina Novak Julia Reifenberger Bernhard Homey Waldemar Kolanus Harri Alenius Irmgard Förster

Chemokines are known to regulate the steady-state and inflammatory migration of cutaneous dendritic cells (DCs). The beta-chemokine CCL17, a ligand of CCR4, is inducibly expressed in a subset of DCs and is strongly up-regulated in atopic diseases. Using an atopic dermatitis model, we show that CCL17-deficient mice develop acanthosis as WT mice, whereas dermal inflammation, T helper 2-type cytok...

Journal: :Journal of immunology 2004
John A Belperio Maria Dy Lynne Murray Marie D Burdick Ying Y Xue Robert M Strieter Michael P Keane

Increasing evidence suggests that the development of pulmonary fibrosis is a Th2-mediated process. We hypothesized that the CC chemokines that are associated with a Th2 profile (CCL17 and CCL22) have an important role in the development of pulmonary fibrosis. We measured CCL17 and CCL22 during the pathogenesis of bleomycin-induced pulmonary fibrosis. We found that both CCL17 and CCL22 were sign...

2017
Kevin Budding Jessica van Setten Eduard A. van de Graaf Oliver A. van Rossum Tineke Kardol-Hoefnagel Erik-Jan D. Oudijk C. Erik Hack Henderikus G. Otten

Lung transplantation (LTx) outcome is hampered by development of chronic rejection, often manifested as the bronchiolitis obliterans syndrome (BOS). Low serum levels of thymus and activation-regulated chemokine (TARC/CCL17), a chemoattractant, measured during the first month post-LTx are predictive for BOS development. Since TARC/CCL17 promotor polymorphisms correlate with serum TARC/CCL17 leve...

Journal: :Biochemical and biophysical research communications 2014
Amr A Al-Haidari Ingvar Syk Henrik Thorlacius

BACKGROUND Simvastatin is widely used to lower cholesterol levels in patients with cardiovascular diseases, although accumulating evidence suggests that statins, such as simvastatin, also exert numerous anti-tumoral effects. AIM The aim of this study was to examine the effect of simvastatin on colon cancer cell migration. METHODS Migration assays were performed to evaluate CCL17-induced col...

2013
Sandra Santulli-Marotto Ken Boakye Eilyn Lacy Sheng-Jiun Wu Jennifer Luongo Karl Kavalkovich Ana Coelho Cory M. Hogaboam Mary Ryan

CCL17 (TARC) function can be completely abolished by mAbs that block either one of two distinct sites required for CCR4 signaling. This chemokine is elevated in sera of asthma patients and is responsible for establishing inflammatory sites through CCR4-mediated recruitment of immune cells. CCL17 shares the GPCR CCR4, with CCL22 (MDC) but these two chemokines differentially affect the immune res...

Journal: :Arthritis and rheumatism 2010
Tomáš Dallos Gisela Ruiz Heiland Johanna Strehl Thomas Karonitsch Wolfgang L Gross Frank Moosig Constanze Holl-Ulrich Jörg H W Distler Bernhard Manger Georg Schett Jochen Zwerina

OBJECTIVE Churg-Strauss syndrome (CSS) is a Th2-mediated systemic vasculitis characterized by eosinophilic infiltration, blood eosinophilia, and high IgE levels. CCL17/thymus and activation-regulated chemokine (TARC) is a chemokine responsible for the recruitment of Th2 cells. This study was undertaken to explore a possible role of CCL17/TARC in CSS. METHODS CCL17/TARC levels in serum from pa...

Journal: :Journal of immunology 2013
Masayuki Kitajima Steven F Ziegler

The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the initiation and progression of allergic inflammation through its ability to activate dendritic cells (DCs). However, the identity of the DC subset that responds to TSLP is not known. In this study we use a CCL17 reporter strain to identify the TSLP-responsive DC subset. In vitro, TSLP induced CD11b(high) DCs to express C...

Journal: :Molecular medicine reports 2008
Dick Wågsäter Olaf Dienus Sture Löfgren Anders Hugander Jan Dimberg

Chemokines are believed to play a crucial role in local immunoresponse by regulating leukocyte movement in various tissues, including the intestinal mucosa. It has been suggested that they are key players in cancer biology, and several studies have identified leukocyte infiltration as a hallmark of most cancers. The chemokines CCL17 and CCL22 attract CCR4-bearing cells, which are especially pol...

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