introduction: it is believed that injury potential has a regulatory role in wound healing process and the application of exogenous electrical stimulation may serve to mimic the natural endogenous bioelectric current so that can improve the wound healing. up to now, this hypothesis has not been researched in surgically acute wounds. materials and methods: thirty nine male guinea pigs were random...

background and aim: the normal response of h-reflex depression (hd) was reduced in chronic spinal cord injury (sci) patients. the reduction of this normal response can lead to increase the muscle tone and spasticity. the purpose of this study is to investigate the effect of tripolar cathodal stimulation on hd in sci patients.   materials and methods: this study was conducted in 10 volunteered s...

Background and objective: Drug craving is considered to be a major problem in addiction treatment. Neuroimaging research has revealed various areas for drug craving, among which two key areas are the dorsolateral prefrontal cortex (DLPFC) and the cerebellum. The DLPFC is involved in different cognitive tasks like the inhibitory control over seductive options harboring the promise of immediate r...

PURPOSE To determine electrical thresholds required for extracellular activation of retinal ganglion cells as part of a project to develop an epiretinal prosthesis. METHODS Retinal ganglion cells were recorded extracellularly in retinas isolated from adult New Zealand White rabbits. Electrical current pulses of 100- micro s duration were delivered to the inner surface of the retina from a 5- ...

Resting transmembrane potential (TMP) of primary human fibroblast cells was altered in predictable directions by subjecting cell cultures to specific monophasic and biphasic waveforms. Cells electrically stimulated with an anodal pulse resulted in hyperpolarization while a cathodal waveform depolarized the TMP to below that of non-paced control cells. The biphasic waveform, consisting of an ano...

BACKGROUND AND OBJECTIVE: Diabetic foot ulcer is a major complication caused by diabetes. Electrical stimulation is considered as an efficient modality of diabetic wound healing. This study aimed to investigate the effects of direct-current stimulation of cathodal on skin temperature and acceleration of ischemic diabetic foot ulcer closing. METHODS: This randomized, single-blinded, clinical tri...

We describe EMG responses recorded in active masseter muscles following unilateral and bilateral electrical vestibular stimulation (EVS, current pulses of 5 mA intensity, 2 ms duration, 3 Hz frequency). Averaged responses in unrectified masseter EMG induced by unilateral EVS were examined in 16 healthy subjects; effects induced by bilateral (transmastoid) stimulation were studied in 10 subjects...

We investigated the effects of anodal and cathodal electrical stimulation on wound healing. In a randomized controlled trial, we divided 42 male albino guinea pigs into two control (C1 and C2) and four experimental (E1-E4) groups. A 3 cm linear incision was made at the dorsal skin of all guinea pigs. A unidirectional pulse current of 300 to 600 microamperes, 80 pps, and 0.3 ms pulse duration wa...

Electrical stimulation of retinal neurons offers the possibility of partial restoration of visual function. Challenges in neuroprosthetic applications are the long-term stability of the metal-based devices and the physiological activation of retinal circuitry. In this study, we demonstrate electrical stimulation of different classes of retinal neurons with a multicapacitor array. The array--ins...

Understanding the basic mechanisms of excitability through the cardiac cycle is critical to both the development of new implantable cardiac stimulators and improvement of the pacing protocol. Although numerous works have examined excitability in different phases of the cardiac cycle, no systematic experimental research has been conducted to elucidate the correlation among the virtual electrode ...