conclusions it seems that testosterone in low dose, i.e. physiologic dose, protects kidneys against cp-induced nephrotoxicity; however, special care is needed in cp therapy of patients with high levels of ts. results cp increased the serum levels of blood urea nitrogen (bun), creatinine (cr), and malondialdehyde (smda) as well as kidney weight (kw), bodyweight (bw) loss, and kidney tissue damag...

Neurosteroids are steroids that are produced in the central nervous system (CNS). While progesterone and dehydroepiandostendione (the precursors of testosterone) are among the identified neurosteroids, it is not clear that testosterone could be considered as a neurosteroid. The testosterone synthesis has been demonstrated in the brain of castrated frog, but not in the rat brain. In the present ...

Estrogen has a widespread and complex influence on brain capabilities such as learning and memory. On the other hand, hippocampus as one of the main brain structures has an important role in spatial information processing. There is some evidence on the existence of estrogen receptors in the hippocampal CA1 area. So, in this study the effect of intrahippocampal injection of estradiol benzoate on...

The initiation of protein synthesis by ribosomal particles of rat ventral prostate was studied by measuring ribosomal binding of an initiator (35-S)methionyl-tRNAf. The binding activity is dependent on ribosomes, GTP, and a prostate cytosol protein fraction. The 40S but not the 60S ribosomal subunit particles are active. The cytosol activity decreases rapidly within one hour after the rat is ca...

Neurosteroids are steroids that are produced in the central nervous system (CNS). While progesterone and dehydroepiandostendione (the precursors of testosterone) are among the identified neurosteroids, it is not clear that testosterone could be considered as a neurosteroid. The testosterone synthesis has been demonstrated in the brain of castrated frog, but not in the rat brain. In the present ...

The morphology of the rat lung was studied by light microscopy in different situations: after surgical and pharmacological castration and after administration of testosterone to the castrated rat to determine if the androgen is required to maintain the normal morphology of the lung. We also determined the effect of flutamide on the phospholipid composition of both the surfactant and microsomes ...

Arginine vasopressin (AVP) causes severe motor disturbances, including barrel rotations and myotonic/myoclonic convulsions, following repeated injections into either a lateral cerebral ventricle or the ventral septal area (VSA) of the rat brain. Because the AVP content of the rat septal area has been shown to be virtually eliminated following long-term castration, and because removal of a recep...

It is known that human benign prostatic hyperplasia might arise from an estrogen/androgen (E/T) imbalance. We studied the response of castrated rat prostate to different ratios of circulating E/T. The castrated male Wistar rats were randomly injected with E/T at different ratios for 4 weeks. The prostates of E/T (1:100) group showed a distinct prostatic hyperplasia response by prostatic index, ...

Sex differences, laterality, and hormonal regulation of androgen receptor (AR) immunoreactivity in rat hippocampal CA1 pyramidal cells were examined using the PG21 antibody. Adult male rats were either castrated or sham-operated at least 2 weeks prior to sacrifice. Gonadally intact females were sacrificed on the day of proestrus. Animals received an injection of either testosterone propionate (...