objective: the present study aimed to determine whether castration altered osmotically stimulated vasopressin (vp) release and urinary volume and what is the role of endocrine-stress axis in this process. materials and methods: totally 108 mice were studied in two main groups of castrated (n=78) and control (n=30). each group was extracted by acute cold stress (4◦c for 2h/day), restraint stress...

Roles of Fos in apoptosis of epithelia in the mouse male accessory sex organs and uterus were investigated using Fos-deficient mice. Normal 30- and 50-day-old and Fos-deficient 50-day-old male and female mice were castrated, and testosterone propionate and estradiol-17 beta were daily injected into male and female mice, respectively, for 5 days. An apoptotic index (a percentage of apoptotic cel...

Brown adipose tissue (BAT) burns substantial amounts of mainly lipids to produce heat. Some studies indicate that BAT activity and core body temperature are lower in males than females. Here we investigated the role testosterone its receptor (the androgen receptor; AR) metabolic male mice. Castration, which renders mice deficient, slightly promoted expression thermogenic markers BAT, decreased ...

In the study, the possible effect of sodium valproate (NaVP) on urethane-induced lung tumors in mice has been evaluated. BALB/c mice (n = 120; 4-6 weeks old, both sexes) were used in the following groups: 1) urethane-treated, 2) urethane-NaVP-treated, 3) only NaVP-treated, 4) control. In the same groups, castrated male mice (n = 48) were investigated. Urethane was given by intraperitoneal injec...

BACKGROUND Ankylosing enthesopathy (ANKENT) with progressive stiffening of ankle and tarsal joints of the hind limbs is a naturally occurring arthropathy in B10.BR mice. Some features are similar to those of the spondyloarthropathies in humans. OBJECTIVE To study the role of sexual dimorphism and testosterone in the development of ANKENT. METHODS The incidence of ANKENT was observed in non-...

Depigmentation of hair shafts is a hallmark human aging. However, it remains unclear how aging causes to grey. Here, we found that single session plucking via waxing grey in castrated mice. Moreover, this greying continued for several cycles. Given androgen secretion decreases with age both male and female humans, the present result suggests decrease may contribute age-related greying. I...

Experimentally obese virgin female C3H mice showed a more marked increase and an earlier incidence of mammary tumors than did normal (weight) controls. When castrated, such animals showed a decrease in tumorigenesis, below that of unoperated obese animals or mice of normal weight. However, such obese castrated animals demonstrated a tumor incidence significantly greater than normal weight, cast...

This study was undertaken to test the effect of immunization against luteinizing hormone-releasing hormone (LHRH) fusion proteins on the development and progression of prostate cancer in the transgenic adenocarcinoma mouse prostate (TRAMP) model. Two LHRH fusion proteins, ovalbumin with seven LHRH peptides (OV-LHRH-7), and thioredoxin with seven LHRH peptides (TH-LHRH-7) were used in a cocktail...

OBJECTIVE To compare the efficacy of early versus delayed surgical castration on prolonging survival and further to investigate the anticancer effect and potential value of targeting androgen in the therapeutic intervention of bladder cancer. MATERIALS AND METHODS N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was used to induce bladder cancer in male mice. Mice were randomly divided into three...

Sarcoma 37 cells grew more rapidly in castrated male mice than in controls of the same genotype; however, this effect of castration was dependent on the host genotype. Among inbred YS/Wf mice, tumor weight was increased only in castrated yellow Ay/a males and not in the comparable black a/a males. In contrast, mean tumor weight was increased in both yellow Avy/a and black a/a castrated males of...