objective: this study aimed to evaluate the incidence of apoptosis in vitrified and non-vitrified human ovarian tissue by the use of morphological analysis and apoptosis assay techniques. methods: we obtained human ovarian tissue biopsies from 30 women who underwent elective caesarean sections. tissues were transported to the laboratory in pre-warmed, equilibrated leibovitz l-15 medium within 2...

econazole nitrate (en), a synthetic compound, is now in use as a routine antifungal drug. en was shown to have antitumor effect, the tumor cell killing mechanisms, however, remain unclear. in this research, the apoptosis-inducing effect of en on mcf-7 cells was investigated. the results showed that en inhibited the proliferation of mcf-7 cells in a time- and dose-dependent manner by mtt method ...

Abstract Background Apoptosis is an important process for organism’s innate immune system to respond pathogens, while also allowing cell differentiation and other essential life functions. Caspases are one of the key protease enzymes involved in apoptotic process, however there currently a very limited understanding bivalve caspase diversity function. Results In this work, we investigated prese...

Mapping the constellation of structural and dynamic changes concurrent with allosteric inhibitor binding to caspase-7, also known as structure–activity relationships (ASARs), reveals nexus between active site remote pocket. These ASARs elucidate link structure catalytic power for caspase-7. Our insights from exploration caspase-7 allostery offer a new path navigating drug discovery. More inform...

Peptic ulcer disease (PUD) is when gastric mucosa gets injured due to the increase of acid and pepsin enzyme. The common risk factors are infection Helicobacter pylori bacteria misused NSAIDs. This review article aims describe role caspase in PUD. Methods used selection articles PubMed. Caspase a protease enzyme that plays an apoptotic inflammatory reaction can be activated dimerized or cleaved...

mycophenolic acid (mpa) is the active metabolite of mycophenolate mofetil. this study designed to investigate the mechanism of cytotoxicity of mpa on the genetically engineered pc12 tet off (pto) neuronal cells with p53 gene. alamar blue (ab) reduction showed concentration-dependent cytotoxicity of mpa on pto cells with ic50 value of 32.32 ± 4.61 mm. the reactive oxygen species (ros) generation...

Cisplatin efficacy is dependent on dose. The cisplatin-induced apoptosis pathway can go through the ER stress which will activate Bax and Bak (proapoptosis) causing calcium homeostasis disorders to occur. Glutamine protective effect caspase-12 expression prevention of apoptotic events in renal proximal tubular epithelial cells unknown. This further study analyzes effects intravenous glutamine c...