INTRODUCTION To determine whether keeping the heart empty and beating is an effective technique to preserve hypertrophied pig hearts, and to investigate the underlying mechanism. METHODS Ten Bama Miniature pigs with hypertrophied hearts were divided into 2 groups (n = 5 in each group). One group underwent normothermic normokalemic simultaneous perfusion (NNSP). The other group was subjected t...

BACKGROUND Lysophosphatidylcholine (lysoPC), a metabolite from membrane phospholipids, accumulates in the ischemic myocardium and plays an important role in the development of myocardial dysfunction ventricular arrhythmia. In this study, we investigated if baicalein, a major component of Huang Qui, can protect against lysoPC-induced cytotoxicity in rat H9c2 embryonic cardiomyocytes. METHODS C...

we aimed to develop a cost-effective and robust method to predict drug resistance in individualpatients. representative tissue fragments were obtained from tumors removed from femalepatients, aged 24-74 years old. the tumor tissue was taken by a histopathology’s or a surgeonunder sterile conditions. cells obtained by enzymatic dissociation from tumor after surgery, werecultured as a monolayer f...

BACKGROUND: Cyclooxygenase-2 (COX)-2 inhibitor (Celecoxib) is a non-steroidal antiinflammatory drug (NSAIDs) and over-expression of COX-2 protein and mRNA has been reported in various cancer tissues. Therefore, it has been suggested that COX-2 is related to carcinogenesis. METHODS: Twenty five albino rats were used .They were divided into 3 groups; group I (normal control) and group II and III ...

Rasfonin (A304) was originally extracted from the Taleromyces sp. and Trichurus terrophilus , and was found to have the inhibitory activity on cancer cells. However, the underlying mechanism of its regulatory role in autophagy and programmed cell death remains largely unknown. In present study, the A304-induced cell death was first detected using human renal cancer cell line ACHN. A304 caused c...

The association of secreted frizzled related protein type 4 (Sfrp4) as an antagonist of Wnt mole-cules in apoptotic events has been reported previously. Moreover, its increased expression has been reported in the ovary of women with polycystic ovary (PCO). We have demonstrated in-creased Sfrp4 in PCO-induced rat ovary related to an increased number of apoptotic follicles showing nuclear ?cateni...

the association of secreted frizzled related protein type 4 (sfrp4) as an antagonist of wnt mole-cules in apoptotic events has been reported previously. moreover, its increased expression has been reported in the ovary of women with polycystic ovary (pco). we have demonstrated in-creased sfrp4 in pco-induced rat ovary related to an increased number of apoptotic follicles showing nuclear ?cateni...

We aimed to develop a cost-effective and robust method to predict drug resistance in individualpatients. Representative tissue fragments were obtained from tumors removed from femalepatients, aged 24-74 years old. The tumor tissue was taken by a histopathology’s or a surgeonunder sterile conditions. Cells obtained by enzymatic dissociation from tumor after surgery, werecultured as a monolayer f...

We aimed to develop a cost-effective and robust method to predict drug resistance in individualpatients. Representative tissue fragments were obtained from tumors removed from femalepatients, aged 24-74 years old. The tumor tissue was taken by a histopathology’s or a surgeonunder sterile conditions. Cells obtained by enzymatic dissociation from tumor after surgery, werecultured as a monolayer f...