نتایج جستجو برای: carnosol

تعداد نتایج: 140  

Journal: :International journal of oncology 2014
Ki-Woong Park Juthika Kundu In-Gyeong Chae Do-Hee Kim Mi-Hee Yu Joydeb Kumar Kundu Kyung-Soo Chun

Carnosol, an active constituent of rosemary, has been reported to possess anti-inflammatory and anticancer activities. However, the molecular mechanisms underlying the anticancer effects of carnosol remain poorly understood. In the present study, we found that carnosol significantly reduced the viability of human colon cancer (HCT116) cells in a concentration- and time-dependent manner. Treatme...

2014
Yusra Al Dhaheri Samir Attoub Gaber Ramadan Kholoud Arafat Khuloud Bajbouj Noushad Karuvantevida Synan AbuQamar Ali Eid Rabah Iratni Hiroyasu Nakano

BACKGROUND In this study we investigated the in vitro and in vivo anticancer effect of carnosol, a naturally occurring polyphenol, in triple negative breast cancer. RESULTS We found that carnosol significantly inhibited the viability and colony growth induced G2 arrest in the triple negative MDA-MB-231. Blockade of the cell cycle was associated with increased p21/WAF1 expression and downregul...

2017
Do Yeon Lee Chul Ju Hwang Ji Yeon Choi Mi Hee Park Min Ji Song Ki Wan Oh Dong Ju Son Seung Hwa Lee Sang Bae Han Jin Tae Hong

Carnosol is a phenolic antioxidant present in rosemary (Rosmarinus officinalis). It is known for anti-inflammatory effects, analgesic activity and anti-cancer effects. However, no study has been dedicated yet to its effect on atopic dermatitis (AD). Here, we show that carnosol effectively inhibited LPS-induced nitric oxide (NO) generation and expression of inflammatory marker proteins (iNOS and...

Journal: :Molecular medicine reports 2014
Hui Yao Yufeng Chen Longjuan Zhang Xiaosheng He Xiaowen He Lei Lian Xiaojian Wu Ping Lan

Inflammatory bowel diseases (IBD) are gastrointestinal disorders associated with chronic inflammatory processes. Carnosol has been demonstrated to possess anti-inflammatory properties. This study examined the suppressive effect of carnosol on the expression of cell adhesion molecules (CAMs) and chemokines in human umbilical vein endothelial cells (HUVECs) and the possible underlying mechanism. ...

2015
Christelle Sanchez Marie-Noëlle Horcajada Fanny Membrez Scalfo Laurent Ameye Elizabeth Offord Yves Henrotin Oreste Gualillo

AIM The aim of this work was to evaluate the effects of carnosol, a rosemary polyphenol, on pro-inflammatory and catabolic mediators of cartilage breakdown in chondrocytes and via bone-cartilage crosstalk. MATERIALS AND METHODS Osteoarthritic (OA) human chondrocytes were cultured in alginate beads for 4 days in presence or absence of carnosol (6 nM to 9 μM). The production of aggrecan, matrix...

Journal: :The Journal of biological chemistry 2004
Daniel Martin Ana I Rojo Marta Salinas Raquel Diaz German Gallardo Jawed Alam Carlos M Ruiz De Galarreta Antonio Cuadrado

The phosphatidylinositol 3-kinase (PI3K)/Akt pathway elicits a survival signal against multiple apoptotic insults. In addition, phase II enzymes such as heme oxygenase-1 (HO-1) protect cells against diverse toxins and oxidative stress. In this work, we describe a link between these defense systems at the level of transcriptional regulation of the antioxidant enzyme HO-1. The herb-derived phenol...

Journal: :Biological & pharmaceutical bulletin 2012
Pi-wen Zhao David Yue-wei Lee Zhong-ze Ma Lian-sha Huang Li-ping Sun Ya-dong Li Jia-xu Chen Jian-zhao Niu

Antioxidant action is critical for maintaining the normal cardiovascular function and vascular endothelial cell is an important target of estrogen action through estrogen receptor (ER) pathway. This study is carried out to explore the antioxidant effect of carnosol in bovine aortic endothelial cells (BAECs) via ER pathway. The ER subtype specific estrogenic effect of carnosol was further demons...

2016
Imran Khan Nasiara Karim Waqar Ahmad Abeer Abdelhalim Mary Chebib

Artemisia indica, also known as "Mugwort," has been widely used in traditional medicines. However, few studies have investigated the effects of nonvolatile components of Artemisia indica on central nervous system's function. Fractionation of Artemisia indica led to the isolation of carnosol, ursolic acid, and oleanolic acid which were evaluated for their effects on GABA-A receptors in electroph...

Journal: :Journal of agricultural and food chemistry 2007
Evelyne H A Doolaege Katleen Raes Karen Smet Mirjana Andjelkovic Christof Van Poucke Stefaan De Smet Roland Verhé

In this study, two unknown compounds in rosemary oil, containing 3% carnosic acid and 0.3% carnosol, were identified and characterized. After methanol extraction, purification, and analysis by reversed-phase HPLC and LC-MS, a recovery of 92% (+/-8%) of carnosic acid was obtained, but no carnosol was found. However, two unknown compounds with a molecular weight of 330.2 and 302.2 were consistent...

Journal: :Plant physiology 2017
Margot Loussouarn Anja Krieger-Liszkay Ljubica Svilar Antoine Bily Simona Birtić Michel Havaux

Carnosic acid, a phenolic diterpene specific to the Lamiaceae family, is highly abundant in rosemary (Rosmarinus officinalis). Despite numerous industrial and medicinal/pharmaceutical applications of its antioxidative features, this compound in planta and its antioxidant mechanism have received little attention, except a few studies of rosemary plants under natural conditions. In vitro analyses...

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