نتایج جستجو برای: cardiac hypertrophy
تعداد نتایج: 305267 فیلتر نتایج به سال:
buckwheat rutin has been found to be able to inhibit angiotensin ii (angii) - induced hypertrophy in cultured neonatal rat cardiomyocytes, but the mechanism remains uncertain. in this study, myocardial hypertrophy model was made by adding angii to the medium of cardiac myocytes of neonatal rats, meanwhile, different concentrations of buckwheat rutin were applied to observe their effects. intrac...
Background and Objective: The androgens cause the cardiac hypertrophy and cardiomyopathy. There are reports of garlic protective effects in the cardiac hypertrophy due to overload and catecholamine. The aim of this study was to investigate the effects of garlic powder on testosterone-induced cardiac hypertrophy in rats. Materials and Methods: This experimental study was performed on Wistar mal...
Pathological cardiac hypertrophy was produced by partial abdominal aortic constriction (PAAC) for 4 wk, while physiological cardiac hypertrophy was produced by chronic swimming training (CST) for 8 wk in rats. Pentoxifylline (30 mg/kg, 300 mg/kg i.p., day-1) treatment was started three days before PAAC and CST and it was continued for 4 wk in PAAC and 8 wk in CST experimental model. The left ve...
Introduction:Severe abdominal aortic constriction above the renal arteries induces arterial hypertension above the stenotic site that is the cause of cardiac hypertrophy. Previous studies have shown that high blood pressure induces myocardial oxidative stress with conflicting results. In the present study, we assessed the effects of acute hypertension on the myocardial oxidative stress an...
Background and Aim: Previous studies have shown that arterial hypertension induces cardiac hypertrophy and myocardial oxidative stress. The aim of the present study was to assess the effects of treatment by atorvastatin, as an antioxidant, to prevent myocardial oxidative stress and cardiac hypertrophy in hypertensive rats. Materials and Methods: In this experimental study, 20 male Wistar rats w...
Background and Objective: In this study the effect of high intensity interval training on miR-29 expression that is expressed in the heart and in the regulation of physiological processes, including extracellular matrix and cardiac hypertrophy of healthy male rats were examined. Materials and Methods: 16 Wistar rats were divided into training (n=8) and control (n=8) groups. After one week of fa...
The role of Pygo1 in mammalian cardiac disease remains unelucidated. In this study, we found that is associated with human pathological hypertrophy. Cardiac-specific overexpression mice spontaneously led to hypertrophy, accompanied by declined function, increased heart weight/body weight and weight/tibial length ratios, cell size. Meanwhile, function was improved when expression interfered hype...
Introduction: Increased serum levels of FGF23 is associated with left ventricular hypertrophy. Increased serum ACE probably plays a role in cardiovascular disease and negatively affects the structure and function of cardiac muscle and leads to an induction of pathologic concentric hypertrophy. The aim of the present study was to investigate the effect of 12 weeks aerobic exercise on plasma FGF2...
Hypertrophic cardiomyopathy (HCM) is a heterogeneous myocardial disease characterized by hypertrophy, mechanical and electrical activity obstacles. This study aimed to explore the relationship between YAP2 (Yes-associated protein 2) HCM clarify signaling path about pathogenesis of HCM. Our confirms that can promote cell hypertrophy at molecular level (myocardial lineage H9C2), organ (clinical s...
Background: Obesity is associated with cardiovascular disease, followed by pathological cardiac hypertrophy. However, physical activity (resistance training) plays a role in modulating some of the intracellular messenger pathways associated with the regulation of pathologic hypertrophy. The aim of this study was to investigate The effect of resistance training on the expression of cardiac muscl...
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