In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

in this study, the effects of various hydrophilic (hpmc and carbopol 971) and plastic (ethylcellulose and eudragit rl100) polymers on the release profile of diltiazem hcl from matrix tablets were evaluated in-vitro. for this purpose, tablets containing 60 mg of diltiazem hcl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. tablets prep...

In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

Objective: The main objective of the current research work was to formulate and evaluate Bosewellia serrata extract loaded transferosomal topical gels. To overcome drawbacks associated with oral administration in Osteoarthritis treatment. Methodology: Transferosomes were developed using different ratios Phospholipon® 90G as phospholipid, Span-60 surfactant cholesterol fluidity buffer. selected ...

The matrix tablets were prepared by using Eudragit L 100, Poly ethylene oxide and Carbopol 971 P. The granules of Zidovudine using above polymers were prepared by direct mixing, wet granulation with water and wet granulation with IPA. The granules were characterized for the morphological study, bulk density, tapped density and particle size distribution. The granules were compressed in to table...

The main objective of this research is to develop and characterize a series of carbopol 934 (CP) hydroxypropyl methylcellulose (HPMC) and a combination of carbopol-HPMC as a gel base for topical delivery of nystatin. The drug level was held constant at 1.72% w/w and the level of propylene glycol which is used as a co-solvent and penetration enhancer was also kept constant at 2% w/w. The total l...

The aim of this study was to assess the influence of qualitative and quantitative base composition on pharmaceutical availability of metronidazole. Hydrogels contain water dispersion of 2% Carbopol 971P and various concentration of glycerol, polyethylene glycol and propylene glycol were preparated. Produced formulations were neutralized to the pH 6.0-6.5 with triethanolamine, and metronidazole ...

1. The mechanism of interaction of the polyacrylates, carbopols with the mucus barrier in vivo has been investigated in vitro. 2. Carbopol caused a dramatic increase in the viscosity of porcine gastric mucin solutions that was up to 19-fold greater than that of the sum of the individual polymers. 3. The mucin-carbopol interaction was stable after an initial 30 min period for up to 36 h at 25 de...

Within the current study, a delivery system based on a novel polymer-lectin conjugate (carbopol-lectin) was evaluated for the oral delivery of therapeutic peptides and proteins. It was demonstrated that covalent attachment of lectin to carbopol does neither decrease nor abolish the specific binding properties of lectin. Bioadhesion studies revealed that liposomes coated with carbopol lectin are...