1. Collagenolytic activity towards acid-soluble collagen labelled with [(14)C]-proline was assayed in rat liver with and without carbon tetrachloride poisoning. The products of enzymic digestion were found to be free amino acids and peptides. 2. The hepatic collagenolytic activity increased under conditions of single-dose and subacute carbon tetrachloride poisoning, and correlated with hydroxyp...

conclusions the results of this study showed that arbutin may protect the liver against ccl4-induced oxidative damage in rats. this hepatoprotective effect might be correlated with the antioxidant and free radical scavenger effects of arbutin. results treatment with ccl4 for 28 d decreased the levels of total protein and albumin and increased the level of bilirubin and lipid peroxidation. arbut...

Recent work in our laboratory, carried out in collaboration with Dr. M. C. Schotz, has led to the formulation of a simple hypothesis regarding the pathogenesis of carbon tetrachloride fat accumulation. This hypothesis consists essentially of an extension of the work of Byers and Friedman (1) to the carbon tetrachloride-poisoned liver. These workers have recently shown that the liver is constant...

Recent work in our laboratory, carried out in collaboration with Dr. M. C. Schotz, has led to the formulation of a simple hypothesis regarding the pathogenesis of carbon tetrachloride fat accumulation. This hypothesis consists essentially of an extension of the work of Byers and Friedman (1) to the carbon tetrachloride-poisoned liver. These workers have recently shown that the liver is constant...

The effect of administration of carbon tetrachloride and dimethylnitrosamine in vivo on hepatic microsomal function related to drug metabolism was measured. It was found that the capacity of isolated microsomes to demethylate dimethylaniline was diminished during the first hour after carbon tetrachloride poisoning and during the second hour after dimethylnitrosamine poisoning. Thereafter the mi...