Carbimazole is a common treatment for hyperthyroidism in the UK. Its main side effects include a rash, agranulocytosis and rarely a lupus-like syndrome. Although vasculitis associated with antineutrophil anticytoplasmic antibodies (ANCA) has been reported on several occasions following treatment with propylthiouracil, vasculitis with carbimazole appears to be less common. We report a case of le...

HIGHLIGHTS Propolis combinations with carbimazole or levothyroxine have an effect on blood in female rats. Carbimazole dose of 0.01mg /g for six weeks causes renal damage Levothyroxine 0.1µg/g degenerative effects. Iraqi PR 50mg/kg a protective effect.

The concept of a carbimazole embryopathy underlies current Endocrine Society advice to avoid this drug in early pregnancy, favouring propylthiouracil as an alternative for the treatment of maternal hyperthyroidism. We aimed to establish whether suspected spontaneous reporting of adverse drug reactions in the UK via the Yellow Card Scheme supports a carbimazole embryopathy and the lack of associ...

The aim of this study was to evaluate the probable protective effect of α-lipoic acid against testicular toxicity in rats exposed to carbimazole during the embryonic period. Time-mated pregnant rats were exposed to carbimazole from the embryonic days 9-21. After completion of the gestation period, all the rats were allowed to deliver pups and weaned. At postnatal day 100, F1 male pups were asse...

Carbimazole is an antithyroid drug used in treatment of hyperthyroidism. The present study is undertaken to evaluate the effect of carbimazole in prostate of albino rats and the ameliorative role of selenium. Treating rats with carbimazole(1.35mg/Kg b.w) daily for 8 weeks caused distinct histological alterations in prostate gland compared with control group. The epithelial cells of prostatic ac...

cell adhesion molecule-1 (PECAM-1, CD31). Because the chemical analog of carbimazole, thiamazole (3-methyl-2-thioimidazole), is widely used for the treatment of hyperthyroidism in the US, we asked the question whether carbimazole DDAbs cross-reacted with thiamazole. Sera from 4 patients of our initial study (patients 2-5; patient 1 died and no further serum was available) were analyzed by enzym...

stressed the freedom from toxicity and potency of carbimazole as an anti-thyroid drug. Though potent, thiourea derivatives had proved to have a significant toxic risk. For this reason, most recent workers have concentrated on a comparison of carbimazole with thiourea drugs in regard to studies of toxicity. McGavack, et al. (1956), in describing their experiences in forty-one cases with special ...

We report two patients whose thyrotoxicosis failed to respond to conventional treatment with carbimazole. The patients remained persistently hyperthyroid, both clinically and biochemically, despite several months of carbimazole therapy at the maximum recommended doses. Prednisolone 20 mg per day was then given in addition to the antithyroid drug and a dramatic response observed in both cases. T...

volume, and total lung capacity.5 Any reduction in pulmonary mechanical efficiency must be avoided in respiratory failure, and controlled use of carbimazole may permit a fall in basal metabolic oxygen requirement but with thyroid function remaining within the normal range. Carbimazole would seem suitable for a double-blind controlled trial of treatment in chronic irreversible respiratory failur...