Postpartum haemorrhage is the leading cause of maternal mortality worldwide: 67-80% of cases are caused by uterine atony. Preventive measures include prophylactic drug use to aid uterine contraction after delivery, thus avoiding severe blood loss and reducing maternal morbidity and mortality. Carbetocin is a synthetic analogue of oxytocin with a half-life approximately 4-10 times longer than th...

AIM To evaluate the cost effectiveness of carbetocin compared to oxytocin when used as prophylaxis against post-partum hemorrhage (PPH) during cesarean deliveries. METHODS A systematic review of the literature was performed to identify randomized controlled trials that compared the use of carbetocin to oxytocin in the context of cesarean deliveries. Cost effectiveness analysis was then perfor...

BACKGROUND Little is known about maternal hemodynamics after Cesarean delivery. Uterine contractions may increase cardiac output. Oxytocin is the first-line treatment for uterine atony, although the effects of the long-acting oxytocin analogue carbetocin are comparable with that of oxytocin. The authors analyzed the effects of i.v. oxytocin 5 U, carbetocin 100 µg, and placebo on hemodynamics, u...

Purpose To compare the incidence of nausea, vomiting, and arterial hypotension between carbetocin and oxytocin to prevent haemorrhage after caesarean section (CS). Methods A randomized controlled trial in term pregnant women undergoing planned CS. Groups were randomized to carbetocin or oxytocin. Blood pressure (BP), heart rate, presence of nausea/vomitus, and need for vasopressors were evalu...

Purpose The aim of the study was to compare the prophylactic effects of carbetocin with those of oxytocin for the prevention of uterine atony in patients undergoing elective caesarean section (CS) in the Netherlands. The primary endpoint was the need for additional uterotonic medication. Methods Each of the five participating Dutch hospitals treated 50–100 term patients with 100 lg of intraveno...

Objectives: The aims of the present study were to compare the efficacy of oxytocin bolus alone, oxytocin bolus and infusion, carbetocin bolus alone, and carbetocin bolus followed by oxytocin infusion in reducing blood loss during and after cesarean section and reducing the needs for additional uterotonic agents. Methods: 200 women scheduled for elective CS under spinal anaesthesia were divided ...

Methodology: This retrospective observational study included 724 patients with GA between (37-42) weeks .Patients were allocated into four groups according to managed received. All patients received conventional resuscitative measures gp(1) received 100μg of carbetocin with aortic compression gp(2) received carbetocin injection the same dose listed above, gp(3) manual aortic compression gp(4) r...

BACKGROUND Postpartum hemorrhage is a significant cause of maternal mortality and morbidity, worldwide. OBJECTIVES The aim of this study was to compare the efficacy between carbetocin and syntometrine in prevention of postpartum hemorrhage. MATERIALS AND METHODS This study was a double blind randomized clinical trial that carried out on 200 pregnant women referred to Shabiehkhani maternity c...

To determine the intercyclic effect of oxytocin and carbetocin on equine myometrial tissue, the effect of the drugs was evaluated through pharmacokinetic and pharmacodynamic studies. The complete pharmacokinetic profile for oxytocin was unknown and had to be established. To do so, 25 IU of oxytocin were administered intravenously to six cycling mares and blood samples were collected before and ...

OBJECTIVES the aims of the present study were to compare the haemodynamic effects of oxytocin and carbetocin and to assess the efficacy of these two drugs in terms of blood loss and the additional uterotonic needed in caesarean section at high risk of primary post-partum haemorrhage. METHODS women in the carbetocin group (group A) received a bolus of 100 μg IV; women in the control group (gro...