conclusions the early signs and symptoms of iscls may be subtle; therefore the diagnosis can easily be missed and prompt treatment of the syndrome may be postponed. thus, the clinician must consider iscls in differential diagnosis in cases of hypotension, hemoconcentration, and hypoalbuminemia. case presentation we present a 58-year-old female who presented with peripheral edema, leg pain, and ...

Systemic capillary leak syndrome is characterized by recurrent hypovolemic shock attributable to increased systemic capillary leakage. A 26-year-old woman was admitted because of recurrent episodes of hypovolemic shock. Hemoconcentration, hypoalbuminemia, and monoclonal gammopathy were observed. We diagnosed systemic capillary leak syndrome. Three years later, she again had an attack of systemi...

background: aluminum phosphide is the common cause of poisoning in adults in india, with a very high case fatality ratio. we studied five patients of aluminum phosphide poisoning with polyserositis. methods: we enrolled all patients with aluminum phosphide poisoning presenting to emergency medical department, at a tertiary care hospital in northwestern india from january to july 2006. these pat...

1. Druey KM, Greipp PR. Narrative review: The systemic capillary leak syndrome. Ann Intern Med. 2010;153:90--8. 2. Kapoor P, Greipp PT, Schaefer EW, Mandrekar SJ, Kamal AH, Gonzalez-Paz NC, et al. Idiopathic systemic capillary leak syndrome (Clarkson’s Disease): The Mayo Clinic Experience. Mayo Clin Proc. 2010;85:905--12. 3. Gousseff M, Arnaud L, Lambert M, Hot A, Hamidou M, Duhaut P, et al. Th...

A 40-year-old woman was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein with the presence of monoclonal IgG-lambda. She had had a similar episode of generalized edema 2 years previously. We diagnosed the patient as having typical systemic capillary leak syndrome (SCLS) and she impr...

Results: Of the 34 patients whose records were reviewed, 25 fulfilled all diagnostic criteria for SCLS. The median age at diagnosis of SCLS was 44 years. Median follow-up of surviving patients was 4.9 years, and median time to diagnosis from symptom onset was 1.1 years (interquartile range, 0.5-4.1 years). Flulike illness or myalgia was reported by 14 patients (56%) at onset of an acute attack ...