OBJECTIVES To evaluate the hypoglycemic and anti-diabetic activity of chloroform extract of Calotropis gigantea leaves and flowers in normal rats and streptozotocin induced diabetes. METHODS The hypoglycemic activity in normal rats was carried out by treatment using chloroform extract of Calotropis gigantea leaf and flower 10, 20 and 50 mg/kg, orally. The oral glucose tolerance test was carri...

Background: Calotropis gigantea of family Asclepiadaceae, is traditionally used in ayurveda for its anti-helminthic, anti-pyretic, and anti-malarial activities. The present study was designed to investigate the sub-acute toxic effects of ethanol and methanol extract of Calotropis gigantea latex in mouse model using haematology, serum biochemistry and histopathological changes as toxicity indice...

As part of a scientific appraisal of some of the folkloric and ethnomedical uses of Calotropis gigantea L. (Family: Asclepiadaceae), the present study was designed to evaluate the antitumour activity of the Calotropis gigantea flower against Ehrlich’s ascites carcinoma (EAC) by using a crude ethyl acetate extract from the flower of Calotropis gigantea (designated as EECF) in Swiss mice. EECF wa...

Swarnabhasma, an Ayurvedic preparation containing Calotropis gigantea R. Br. (Asclepiadaceae) is extensively used by Ayurvedic physicians for treatment of diabetes mellitus, bronchial asthma, rheumatoid arthritis and nervous disorders. In the present study, we report the effect of chloroform extracts of Calotropis gigantea leaf and flower on free radical scavenging activity, and lipid profile i...

Calotropis gigantea is a common wasteland weed and known for various medicinal properties. The aim of the present study was to screen leaves of Calotropis gigantea for the antimicrobial activity against clinical isolates of bacteria. The aqueous extract of the C. gigantea was studied for its antagonistic activity against Staphylococcus aureus, Escherichia coli, Bacillus cereus, Pseudomonas aeru...

BACKGROUND AND AIMS Calotropis procera and Calotropis gigantea, originally from warm parts of Africa and Asia, are now pan-tropical and in ecological terms considered an indicator of overgrazed, disturbed lands; they grow successfully in dry areas. Variations in water relations, morphology and photosynthesis of the two species growing in the same habitat were studied to assess possible mechanis...

A motivational model of alcohol involvement (M. L. Cooper, M. R. Frone, M. Russell, & P. Mudar, 1995) was replicated and extended by incorporating social antecedents and motives and by testing this model cross-sectionally and longitudinally in a sample of college students. Participants (N = 388) completed a questionnaire battery assessing alcohol use and problems, alcohol expectancies, sensatio...

The present study deals with the cytotoxic activity of cardiac glycosides of Calotropis gigantea (L.) W.T.Aiton; on breast cancer cell line MCF-7. Qualitative screening of methenaloic extract of leaves of Calotropis gigantea for secondary metabolites showed the presence of phenolics, alkaloids, coumarins, saponins, tannins and glycosides. Glycosides were selected for detailed chemical analysis,...

BACKGROUND Over 60% of currently used anti-cancer agents are derived in one-way or another from natural sources, including plants, marine organisms and microorganisms. Calotropis gigantea (Linn.) (Family: Asclepiadaceae) is a perennial shrub and it is used as a traditional folk medicine for the treatment of various health complications. But there is no report on isolation of anticancerous chemi...