background: our purpose was to investigate propolis and its component caffeic acid phenethyl ester (cape) for their antioxidant effects on the brain tissue of rats exposed to ionizing radiation (ir). materials and methods: fifty-four male albino sprague-dawley rats, divided into six groups, were designed as normal control group, cranial irradiation of 5 gray alone, irradiation plus cape, irradi...

Objective: The aim of this study was to investigate the total oxidant status and total antioxidant status of caffeic acid phenethyl ester and methylprednisolone in blunt spinal cord injury in rats. Methods: Twentyfour adult Wistar albino rats were randomised into three groups. Spinal cord injury was performed by the weight-drop model. Group 1 underwent laminectomy followed by spinal cord injury...

background propolis is a natural product of bee and caffeic acid phenethyl ester (cape) is a pharmacologically important product of propolis. results cape prevented growth and proliferation of ags human gastric cancer cell line in a concentration-dependent manner with an ic50 of approximately 60 µm by a 24-hour treatment. also cape caused increased induction of apoptosis in ags cells from 1.37 ...

A series of catechol ring-fluorinated derivatives of caffeic acid phenethyl amide (CAPA) were synthesized and screened for cytoprotective activity against H2O2 induced oxidative stress in human umbilical vein endothelial cells (HUVEC). CAPA and three fluorinated analogs were found to be significantly cytoprotective when compared to control, with no significant difference in cytoprotection betwe...

caffeic acid phenethyl ester(cape) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. a group of heterocyclic esters of caffeic acid was synthesized using mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catechol...

 Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catecho...

Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, (1) has been synthesized by esterification of caffeic acid (2). At a concentration of 10 μM, it completely blocks production of reactive oxygen species (ROS) in human neutrophils and the xantine/xantine oxidase system (3). Besides its well-known antioxidant activity (2,4). CAPE inhibits certain enzyme activities such ...

 Caffeic acid phenethyl ester(CAPE) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. A group of heterocyclic esters of caffeic acid was synthesized using Mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catecho...

Caffeic acid phenethyl ester (CAPE) is a bioactive compound of propolis extract. The literature search elaborates that CAPE possesses antimicrobial, antioxidant, anti-inflammatory, and cytotoxic properties. The principal objective of this review article is to sum up and critically assess the existing data about therapeutic effects of CAPE in different disorders. The findings elaborate that CAPE...