the adipokines, leptin and adiponectin, have a prominent role in the pathogenesis of coronary artery disease (cad). the inflammatory enzyme, myeloperoxidase (mpo) also has an important role in the pathogenesis of cad. association of the adipokines with mpo remains to be resolved in patients with cad. in this case-control study, 100 patients with cad and 100 control subjects were appropriately r...

results the prevalence’s of aa, ac and cc genotypes were 55.2%, 24.1% and 20.7% in cad patients and 51.6%, 40.9% and 7.5% in the control subjects, respectively. the frequencies of the c allele were significantly higher in cad patients compared with control groups (p < 0.05). logistic regression analysis revealed a significant association between the c allele and the risk of cad (or = 1.61, 95%c...

Coronary artery disease (CAD) is a common health problem with a high rate of disability and death. Dyslipidemia and altered metabolism of Apo-lipoproteins are involved in the CAD pathogenesis. The current study investigated two common polymorphisms (rs429358 and rs7412) and promoter DNA methylation status of APOE in the Iranian CAD patients and control subjects. Two hundred angiographi...

The adipokines, leptin and adiponectin, have a prominent role in the pathogenesis of coronary artery disease (CAD). The inflammatory enzyme, myeloperoxidase (MPO) also has an important role in the pathogenesis of CAD. Association of the adipokines with MPO remains to be resolved in patients with CAD. In this case-control study, 100 patients with CAD and 100 control subjects were appropriately r...

conclusion primary and secondary prevention of cad including life style modifications and dietary interventions strongly recommended in iranian population. results the prevalence of cad, coronary risk factors and metabolic syndrome in iran is higher than western countries and similar to some middle east countries. there are limited data with regard to novel coronary risk factors in iran. method...

Proper fibroblast cell migration and differentiation are critical for valve formation and homeostasis, but uncontrolled myofibroblastic activation may precede osteogenic differentiation and calcification. Cadherin-11 (cad-11) is a cell-cell adhesion protein classically expressed at mesenchymal-osteoblast interfaces that participates in mesenchymal differentiation to osteochondral lineages. This...

The worldwide increasing prevalence of obesity and sedentary lifestyle is the main cause of the rising incidence of T2DM. Due to chronic macrovascular and microvascular complications, T2DM represent a huge socioeconomic burden in the world. Oxidative stress is a key pathogenic mechanism implicated in diabetic coronary artery disease (CAD). Polymorphisms of oxidative stress genes are known to in...

Inflammatory process plays a fundamental role in ischemic coronary artery disease (CAD) in terms of both the etiology of atherosclerosis and the pathophysiology of CAD. In particular, chronic inflammation plays a key role in coronary artery plaque instability and subsequent occlusive thrombosis. It is therefore important to clarify the mechanism underlying the activation of the immune response ...