Abstract The ratio of poly(lactic acid) (PLA), poly(butylene adipate- co -terephthalate) (PBAT), and calcium carbonate (CaCO 3 ) fillers in PLA/PBAT/CaCO composites was set at 90/10/5, 70/30/5, 30/70/5. effect nano- micro-CaCO on the melting crystallization performance investigated by differential scanning calorimetry. PLA related to PBAT ratio, cooling rate, CaCO particle size composites. Nano...

background and objectives: in the original in vitro method for evaluation of iron bioavailability using caco-2 cell model, ferritin formation by cells is considered as a functional indicator of both absorption and utilization of iron. however, as iron is measured in the tested material and then ferritin concentration is measured in caco-2 cell lysate, it is almost impossible to have a concrete ...

the uptake and transport of 9-nitrocamptothecin (9-nc), a potent anticancer agent, across caco-2 cell monolayers was studied as a free and plga nanoparticle loaded drug. different sizes (110 to 950 nm) of 9-nitrocamptothecin nanoparticles using poly (lactic-glycolic acid) were prepared by via the nanoprecipitation method. the transport of nanoparticles across the caco-2 cell monolayer as a func...

A series of arylketo-containing P1-P3 linked macrocyclic BACE-1 inhibitors were designed, synthesized, and compared with compounds with a previously known and extensively studied corresponding P2 isophthalamide moiety with the aim to improve on permeability whilst retaining the enzyme- and cell-based activities. Several inhibitors displayed substantial increases in Caco-2 cell-based permeabilit...

To increase the intestinal delivery of dietary β-carotene, there is a need to develop nanostructured food systems encapsulate this fat soluble bioactive. The aim study was evaluate bioacessibility and bioavailability across barrier β-carotene-enriched nanoemulsions stabilised with two emulsifiers (lecithin or sodium caseinate) by coupling an in vitro gastrointestinal digestion cell culture mode...

This study investigates the effects of calcium carbonate (CaCO(3)) nanoparticles on the mechanical and thermal properties and surface morphology of polycaprolactone (PCL)/chitosan nanocomposites. The nanocomposites of PCL/chitosan/CaCO(3) were prepared using a melt blending technique. Transmission electron microscopy (TEM) results indicate the average size of nanoparticles to be approximately 6...

a r t i c l e i n f o Keywords: paleoceanography carbonate sedimentology aqueous geochemistry Observed changes in the source of CaCO 3 sediments since Archean time suggest a first order pattern of decreasing abundance of carbonate cements precipitated directly on the seafloor. We propose that the observed reduction in CaCO 3 precipitation on the seafloor is caused by a decrease in CaCO 3 satura...

The Caco-2 cell line is well established as an in vitro model for iron absorption. However, the model does not reflect the regulation of iron absorption by hepcidin produced in the liver. We aimed to develop the Caco-2 model by introducing human liver cells (HepG2) to Caco-2 cells. The Caco-2 and HepG2 epithelia were separated by a liquid compartment, which allowed for epithelial interaction. F...

Para manutenção do ciclo biológico de Schistosoma mansoni em laboratório, é necessário que moluscos hospedeiros intermediários sejam mantidos condições favoráveis para o seu desenvolvimento. a avaliação da biologia reprodutiva (fecundidade e fertilidade), efeito dos nutrientes (alface ração peixe) substratos (argila, mistura sais CaCO₃) suas combinações, foram formados 10 grupos experimentais c...

Calcium is the most abundant mineral in human body and essential for the formation and maintenance of bones and teeth as well as diverse cellular functions. Calcium carbonate (CaCO₃) is widely used as a dietary supplement; however, oral absorption efficiency of CaCO₃ is extremely low, which may be overcome by applying nano-sized materials. In this study, we evaluated the efficacy of food grade ...