Background and study aims Carbohydrate antigen 19-9 (CA199) has been identified as a tumor marker for pancreatic cancer but also increases in benign lesions of the digestive system. However, literature associated with the relationship between CA199 and acute pancreatitis (AP) is limited. This study aimed to focus on serum CA199 level measurements in AP patients and the associated clinical signi...

BACKGROUND This study was designed to investigate the value of CEA and CA199 in predicting the treatment response to palliative chemotherapy for advanced gastric cancer. MATERIALS AND METHODS We studied 189 patients with advanced gastric cancer who received first-line chemotherapy, measured the serum CEA and CA199 levels, used RECIST1.1 as the gold standard and analyzed the value of CEA and C...

AIM To investigate the prognostic value of the combination of preoperative plasma fibrinogen and CA199 in patients with gallbladder carcinoma (GbC). METHODS The clinicopathological data of 154 GbC patients were retrospectively reviewed after surgery. A receiver 1451 April 7, 2018|Volume 24|Issue 13| WJG|www.wjgnet.com ORIGINAL ARTICLE Prognostic significance of combined preoperative fibrinogen ...

PURPOSE Gastric cancer is associated with poor prognosis. The high mortality rate of gastric cancer is mainly attributed to late detection, so diagnosis and treatment are crucial to decreasing mortality. The purpose of this study was to examine the predictive accuracy and discriminative ability of cystic fibrosis transmembrane conductance regulator (CFTR) in gastric cancer patients, in addition...

Carbohydrate antigens (CA) 125 and 199 have now been widely used in diagnosis in lung cancer. However, the role of metastasis and prognosis of these two markers remains controversial and needs further clarification. Here we retrospectively analyzed CA125 and CA199 in 430 lung cancer patients. All patients were categorized to three groups (negative, moderate and high) according to the increased ...

OBJECTIVE Concentrating on oncogenic role and increased plasma expression of microRNA(miR) 106b~25 clusters (involving miR 106b, miR 93 and miR 25), we evaluated significance of the over-expression of plasma miR 106b~25 in GC. METHODS Based on 65 pairs matched GC patients and health controls, we explored clinical significance of miR 106b~25 for GC and compared their diagnostic performance wit...

Lung cancer has the highest morbidity and mortality in malignant tumor worldwide. EGFR-TKI targeted therapy is a type of treatment with low side effects. However, it needs to clarify EGFR mutation status. Limited to sampling, EGFR mutation test cannot be widely applied. Finding other simple and practical markers to predict EGFR mutation state is of great significance. This study aimed to evalua...

Objective To identify the unique clinical features and biological markers of lung cancer-associated stroke. Methods We recruited 102 patients with lung cancer plus stroke, 102 with lung cancer, and 102 with stroke. Detailed information was analysed and compared among groups. Results The groups were age-matched. Patients with lung cancer plus stroke showed multiple lesions involving multiple cer...

MicroRNA-21 was upexpressed in gastric cancer (GC) indicating that it is a potential diagnostic biomarker for GC. In this study, 50 GC patients and 50 healthy controls were recruited. miR-21 levels in serum and peripheral blood mononuclear cells (PBMCs) were quantified using quantitative real-time PCR. CA199, and CEA were measured using electrochemiluminescence assay. The sensitivity and specif...

Objectives: Increased CA199 serum level is a key prognostic factor of carcinoma of the ampulla of vater (CAV) after surgery; the prognostic value of other serum markers like CA242, CEA, LDH, NLR and TBIL has yet not been defined. Methods: We pooled one week pre-treatment data on serum factors from 147 CAV patients in Tumor Hospital of Chinese Academy of Medical Sciences from January 1998 to Dec...