This study sought to develop a biological control agent against gray mold disease caused by Botrytis cinerea in tomato using a strain of Streptomyces, which showed significant antagonistic activity against B. cinerea. Such strain (C51) was screened by dual culture method from a total of 78 actinomycetes and was identified as Streptomyces nobilis by morphological, biochemical and molecular analy...

In this article, we address the issues of stability and data-efficiency in reinforcement learning (RL). A novel RL approach, Kullback-Leibler divergence-regularized distributional (KL-C51) is proposed to integrate advantages both (KL) one framework. KL-C51 derived Bellman equation TD errors regularized by KL divergence a perspective explored approximated strategies properly mapping correspondin...

We have previously demonstrated that cultured rat chloroleukemia cells, MIA C51, will terminally differentiate to macrophages when treated with rat lung-conditioned medium in vitro and in vivo. In the present study we fractionated rat monocyte-conditioned medium by ultrafiltration according to molecular size. The fraction with molecular weight (mol wt) 30 to 50 Kd containing partially purified ...

Financial trading is one of the most popular problems for reinforcement learning in recent years. One important challenges that investment a multi-objective problem. That is, professional investors do not act solely on expected profi t but also carefully consider potential risk given investment. To handle such challenge, previous studies have explored various kinds risk-sensitive rewards, examp...

We have previously demonstrated that cultured rat chloroleukemia cells. MIA C51 . will terminally differentiate to macrophages when treated with rat lung-conditioned medium in vitro and in vivo. In the present study we fractionated rat monocyte-conditioned medium by ultrafiltration according to molecular size. The fraction with molecular weight (mol wt) 30 to 50 Kd containing partially purified...

JEL classification: C51 C52 G11

PURPOSE Radiotherapy modifies the tumor microenvironment and causes the release of tumor antigens, which can enhance the effect of immunotherapy. L19 targets the extra domain B (ED-B) of fibronectin, a marker for tumor neoangiogenesis, and can be used as immunocytokine when coupled to IL2. We hypothesize that radiotherapy in combination with L19-IL2 provides an enhanced antitumor effect, which ...

Purpose: Radiotherapy modifies the tumor microenvironment and causes the release of tumor antigens, which can enhance the effect of immunotherapy. L19 targets the extra domain B (ED-B) of fibronectin, a marker for tumor neoangiogenesis, and can be used as immunocytokine when coupled to IL2. We hypothesize that radiotherapy in combination with L19-IL2 provides an enhanced antitumor effect, which...

In this paper, we propose a C51-Duel-IP (C51 Dueling DQN with Independent Policy) dynamic destination path-planning algorithm to solve the problem of autonomous navigation and avoidance multiple Unmanned Aerial Vehicles (UAVs) in communication denial environment. Our proposed expresses Q function output by network as distribution, which improves fitting ability value. We also extend single-step...