In complex task domains, such as games, students may exceed their teachers. Such tasks afford diverse means to tradeoff one type of performance for another, combining task elements in novel ways to yield method variations and strategy discoveries that, if mastered, might produce large or small leaps in performance. For the researcher interested in the development of extreme expertise in the wil...

Modified 2'-deoxyuridine triphosphates bearing proteinous amino acids at a C5 position were prepared, and their substrate properties were investigated for KOD Dash DNA polymerase during PCR. The modified dUTPs bearing histidyl, lysyl, glutaminyl or seryl group produced the aimed 108 nt PCR products in good yields. In contrast, the analog bearing glutamyl group did not work as a substrate for KO...

The enantioselective total synthesis of thapsigargin, a potent, selective inhibitor of the Ca2+ pump SERCA, is described. Starting from ketoalcohol 8, key steps involve regioselective introduction of the internal olefin at C4-C5, judicious protecting group choice to allow chelation-controlled reduction at C3, and chemoselective introduction of the angelate ester function at C3-O. A selective es...

A new 3D, spin-state-selective coherence transfer NMR experiment is described that yields accurate measurements for eight scalar or dipolar couplings within a spin system composed of a methylene adjacent to a methine group. Implementations of the experiment have been optimized for proteins and for nucleic acids. The experiments are demonstrated for Cbeta-Calpha moieties of the third IgG-binding...

The expression of clinically useful proteins in plants has been bolstered by the development of high-yielding systems for transient protein expression using agroinfiltration. There is a need now to know more about how host plant development and metabolism influence the quantity and quality of recombinant proteins. Endogenous proteolysis is a key determinant of the stability and yield of recombi...

  In this paper, modeling and optimization of Fischer-Tropsch Synthesis is considered in a fixed-bed catalytic reactor using an industrial Fe-Cu-K catalyst. A one dimensional pseudo-homogenous plug flow model without axial dispersion is developed for converting syngas to heavy hydrocarbons. The effects of temperature, pressure, H2 to CO ratio in feed stream, and CO molar flow on the mass flow r...

Catalytic and noncatalytic copyrolysis of plastic heavy oil was studied using thermogravimetric analysis (TGA), pyrolysis reactor experiments, GC the formed liquid. As revealed by TGA predegradation as a pretreatment method had further lowered decomposition temperature polypropylene– (PP?) bitumen mixtures reduced severity catalyst deactivation coke. The presence PP in increased liquid yield de...

in order to optimize use of water resources with selection of suitable wheat genotype(s) and irrigation schedule, in this experiment, the effect of elimination of irrigation at terminal growth and development stages of five wheat genotypes was investigated in two successive growing seasons (2002-03 and 2003-04) in the agricultural research station of torogh mashhad. split plot experiments were ...