c3 typing was performed, by agarose gel electrophorisis, in 147 german patients suffering from hyperlipoproteinemia. the control group consisted of 322 healthy germans. high frequencies of non-typeable sera, varying between 16.66 and 35.71% in different hlp types, found in the present investigation are notable and are a clue for chemical denaturation of c3 protein in hlp patients. statistical a...

BACKGROUND Myocardial infarction (MI) is a major clinical problem because of its large contribution to mortality. The genetic bases of this disease have been widely studied in recent years to find a clear association with some genetic markers that increase the risk of its occurrence. In the present investigation, the correlation between MI and the C3 complement polymorphism was analyzed using a...

background: miscarriage is one of the most common pregnancy complications for which various causes have been defined, such as genetic factors, infectious, metabolic, endocrine systemmal function and immune system undesired responses. the early development of embryo occurs in oviduct and uterine tube from which some factors such as growth factors, glyco-proteins and factors those stimulate devel...

Variations in DNA sequence generate polymorphisms which can be followed through families. A cloned gene specific probe for human complement 3 (C3) was hybridised to DNA samples digested with restriction endonucleases. The C3 probe detects several restriction fragment length polymorphisms (RFLPs) that occur frequently in the general population. These DNA alleles can be readily used in linkage an...

the c3 phenotypes were determined by high-voltage agarose gel electrophoreses in german patients suffering from lymphosarcoma (n=34), hodgkin (n=59) and a group of other haematological diseases (n=46). frequencies of c3 ss, sf and ff pho=enotypes were not significantly different from the frequencies found in a control group of 322 healthy germans. however, high frequency of the ff phenotype in ...

C3 exhibits two common allotypic variants that may be separated by gel electrophoresis and are called C3 fast (C3 F) and C3 slow (C3 S) . C3 F, the less common variant, occurs at appreciable frequencies only in Caucasoid populations (gene frequency = 0.20) . An increased prevalence of the C3 F allele has been reported in patients with partial lipodystrophy, IgA nephropathy, and Indian childhood...

C3 exhibits two common allotypic variants that may be separated by gel electrophoresis and are called C3 fast (C3 F) and C3 slow (C3 S). C3 F, the less common variant, occurs at appreciable frequencies only in Caucasoid populations (gene frequency = 0.20). An increased prevalence of the C3 F allele has been reported in patients with partial lipodystrophy, IgA nephropathy, and Indian childhood h...

Background: There are different etiological factors in spontaneous recurrent abortion which are one of the complications in pregnancy. Primary embryo development in uterine tube and oviduct are affected by different factors such as embryotrophic elements. ETF3 as a embryotrophic factor that contains a complex of complement 3 protein and its derivatives specially iC3b, causes embryo trophoblast ...