Angiogenesis is important for wound healing, tumor growth, and metastasis. Endothelial cells differentiate into capillary-like structures on a laminin1-rich matrix (Matrigel). We previously identified 20 angiogenic sites on laminin-1 (a1b1g1) by screening 559 overlapping synthetic peptides. C16, the most potent g1 chain peptide, blocked laminin-1-mediated adhesion and was the only g1 chain pept...

Laminin peptides influence tumor behavior. In this study, we addressed whether laminin peptide C16 (KAFDITYVRLKF, γ1 chain) would increase invadopodia activity of cells from squamous cell carcinoma (CAL27) and fibrosarcoma (HT1080). We found that C16 stimulates invadopodia activity over time in both cell lines. Rhodamine-conjugated C16 decorates the edge of cells, suggesting a possible binding ...

Self-assembled monolayers (SAMs) were prepared from a novel two-tailed partially fluorinated thiol (F8C11/C16), possessing one hydrocarbon chain and one chain with an extended fluorinated segment, and from mixtures of F8C11/C16 and hexadecanethiol (C16) on gold, with the expectation that the internal chemical dissimilarity and wedge-like shape of F8C11/C16 would lead to unique self-organization...

The enzymatic cleavage of a peptide amphiphile (PA) is investigated. The self-assembly of the cleaved products is distinct from that of the PA substrate. The PA C16-KKFFVLK is cleaved by α-chymotrypsin at two sites leading to products C16-KKF with FVLK and C16-KKFF with VLK. The PA C16-KKFFVLK forms nanotubes and helical ribbons at room temperature. Both PAs C16-KKF and C16-KKFF corresponding t...

BACKGROUND Brain injuries induced by hypoxia-ischemia in neonates contribute to increased mortality and lifelong neurological dysfunction. The specific PKR inhibitor C16 has been previously demonstrated to exert a neuroprotective role in adult brain injuries. However, there is no recent study available concerning its protective role in hypoxia-ischemia-induced immature brain damage. Therefore, ...

BACKGROUND Brown adipose tissue research is in the focus in the field of endocrinology. We designed a dual-modal fluorescent/PET fatty acid based tracer on commercially available Bodipy-C16, which can be synthesized to its corresponding triglyceride and which combines the benefits of fluorescent and PET imaging. METHODS Bodipy-C16 was coupled to 1,3-diolein resulting in Bodipy-triglyceride. B...

Toward the mavacurane and akuammilane monoterpene indole alkaloids, we developed divergent oxidative couplings between nucleus (at N1 or C7) C16-malonate of a common tricyclic model related to strictosidine according biosynthetic hypothesis postulated by Hesse Schmid. These cyclizations led selectively formation N1–C16 bond pleiocarpamine C7–C16 strictamine. We were then able obtain scaffold ta...

A new and sensitive method has been developed to analyze the molecular species of glycerophospholipids. This method was used to examine the effects of hypolipidemic intervention with n-3 fatty acids on the serum phosphatidylcholine species in severely hypertriglyceridemic patients. The drug treated group (n = 19) received 4 g/day of an 85% concentrate of the ethyl esters of eicosapentenoic and ...