BACKGROUND Candida krusei infections are associated with high mortality. In order to explore ways to prevent these infections, we investigated potential routes for nosocomial spread and possible clonality of C. krusei in a haematological unit which had experienced an unusually high incidence of cases. METHODS We searched for C. krusei contamination of the hospital environment and determined t...

A multilocus sequence typing (MLST) scheme for Candida krusei was devised, based on sequencing of six gene fragments of the species. The existence of heterozygous results for each of the six fragments sequenced confirms that C. krusei is diploid for at least part of its genome. The C. krusei MLST scheme had a discriminatory index of 0.998, making this system ideal for strain typing of C. krusei...

BACKGROUND Candida krusei fungaemia is an uncommon entity described in immunocompromised patients previously exposed to azole agents. METHODS From 1988 to 2003, 13 episodes of C. krusei fungaemia (2.3% of all fungaemias) were detected in our institution and compared with 39 Candida albicans controls. Susceptibility testing was carried out with the modified microdilution method according to NC...

BACKGROUND/AIMS The increasing incidence of Candida glabrata and Candida krusei infections is a significant problem because they are generally more resistant to fluconazole. We compared the risk factors associated with C. glabrata and C. krusei fungemia with Candida albicans fungemia and examined the clinical manifestations and prognostic factors associated with candidemia. METHODS We retrosp...

Background and Aim: There are some rich sources of antifungals in medicinal herbs. They have general acceptance due to their low cost and insignificant side effects. The efficacy of Peganum harmala (P. harmala) extract against Candida species was investigated in this study.    Materials and Methods: In this in vitro study, we used the maceration technique to obtain P. harmala aqueous and al...

Candida krusei colonized 12.4% of 868 patients undergoing episodes of therapy-induced granulocytopenia over a 9-year period. The gastrointestinal tract was most frequently colonized, followed by the respiratory tract and urinary tract. Ten patients developed systemic infections with C. krusei; all 10 had two or more positive blood cultures. Nine of the 10 patients were colonized with C. krusei,...

Reactions of cytochromes c from horse heart and Candida krusei (a yeast) were studied at 25” under pseudo-first order conditions by a flow technique. The rate law for the reduction of C. krusei by Cr(I1) (pH 6.0, p = 1.0 M) in chloride is kobs = a[Cr(II)]/(l + b[Cr(II)]), where a and b are 1.0 x 10’ M-’ s-l and 167 f 38 ~-l, respectively. The binding of imidazole (Im) to C. krusei conforms to t...

Reactions of cytochromes c from horse heart and Candida krusei (a yeast) were studied at 25” under pseudo-first order conditions by a flow technique. The rate law for the reduction of C. krusei by Cr(I1) (pH 6.0, p = 1.0 M) in chloride is kobs = a[Cr(II)]/(l + b[Cr(II)]), where a and b are 1.0 x 10’ M-’ s-l and 167 f 38 ~-l, respectively. The binding of imidazole (Im) to C. krusei conforms to t...