Immature renal function in neonates requires antibiotic dosage adjustment. Population pharmacokinetic studies were performed to determine the optimal dosage regimens for three types of antibiotics: an aminoglycoside, arbekacin; a glycopeptide, vancomycin; and a carbapenem, panipenem. Eighty-three neonates received arbekacin (n = 41), vancomycin (n = 19), or panipenem (n = 23). The postconceptio...

background: leishmaniasis is a parasitic infection that may lead to a variety of manifestations. in iran, cutaneous leishmaniasis (cl) has a high prevalence. there are many treatment modalities for cl. the use of oral terbinafine in the treatment of cl has recently been considered. the aim of this study was to compare combination of oral terbinafine plus cryotherapy versus systemic me-glumine a...

in this study, some external morphometric characters viz. carapace width (cw) and length (cl), chelar propodus width (chw) and length (chl) and abdominal width (aw) and also body weight (bw) of the blue swimming crab, portunus pelagicus (linnaeus, 1758), were examined. relative growth and regression slope compared among these parameters between 151 males and 158 females. specimens were collecte...

The food contaminant 5-hydroxymethylfurfural (HMF) is formed by heat- and acid-catalyzed reactions from carbohydrates. More than 80% of HMF is metabolized by oxidation of the aldehyde group in mice and rats. Sulfo conjugation yields mutagenic 5-sulfoxymethylfurfural, the probable cause for the neoplastic effects observed in HMF-treated rodents. Considerable metabolic differences between species...

The apparent oral clearance (CL/F, mL/min) of busulfan was measured in 279 adolescent and adult patients. Significant (P <.05) determinants of CL/F by linear regression were: actual body weight (BW; r2 = 0.300), body surface area (BSA; r2 = 0.277), adjusted ideal body weight (AIBW; r2 = 0.265), and ideal body weight (IBW; r2 = 0.173); whereas body mass index (BMI), height, age, gender, and dise...

The purpose of the present experiments was to compare the effects of the intermittent lighting schedule (IL) consisting of repeated cycles of 1 h light (L):3 h darkness (D) with a nearly continuous lighting schedule 23L:1D (CL) on the performance of floor-reared male and female broiler chickens. In addition, N balance trials were performed on caged broilers in order to assess their efficiency o...

BACKGROUND Leishmaniasis is a parasitic infection that may lead to a variety of manifestations. In Iran, cutaneous leishmaniasis (CL) has a high prevalence. There are many treatment modalities for CL. The use of oral terbinafine in the treatment of CL has recently been considered. The aim of this study was to compare combination of oral terbinafine plus cryotherapy versus systemic meglumine ant...

The population pharmacokinetics of panipenem was studied in 23 neonates. Their postconceptional age (PCA) was 24.7-42.6 weeks and their body weight was 530-4455 g at initiation of therapy. Panipenem was infused over a period of 60 min in a dose of 10.2-34.7 mg/kg bd in 21 patients, tid in one patient and four times daily in one patient for a mean of 10.7 days. Blood samples were obtained just b...

The apparent oral clearance (CL/F, mL/min) of busulfan was measured in 279 adolescent and adult patients. Significant (P F .05) determinants of CL/F by linear regression were: actual body weight (BW; r2 5 0.300), body surface area (BSA; r2 5 0.277), adjusted ideal body weight (AIBW; r2 5 0.265), and ideal body weight (IBW; r2 5 0.173); whereas body mass index (BMI), height, age, gender, and dis...