objective: tabernaemontana divaricata (td) from apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. the aim of the present study was to evaluate the effect of ethanolic extract of td leaves on burying behavior in mice. materials and methods:mice were treated with oral administration (p.o.) of ethanolic extra...

In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor...

Objective: Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice. Materials and Methods:Mice were treated with oral administration (p.o.) of ethanolic extra...

roles in several psychiatric disorders, including depression and anxiety. Obsessive compulsive disorder (OCD) is classified as an anxiety disorder characterized by obsession or compulsion. The burying of harmless objects like marbles by mice may reflect the formation of compulsive behavior. Marble burying behavior in mice is recognized as an animal model for OCD. It has been reported that marbl...

The marble burying test is a simple behavioral psychopharmacology task in which rodents, especially rats and mice, are exposed to glass marbles laying on thick bedding materials. This test has been widely used to assess the effects of a variety of psychoactive drugs. Although the marble burying test clearly reflects drug efficacy, many aspects of the behavior itself remain unclear. In the prese...

Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argent...

OBJECTIVE Tabernaemontana divaricata (TD) from Apocynaceae family offers the traditional folklore medicinal benefits such as an anti-epileptic, anti-mania, brain tonic, and anti-oxidant. The aim of the present study was to evaluate the effect of ethanolic extract of TD leaves on burying behavior in mice. MATERIALS AND METHODS Mice were treated with oral administration (p.o.) of ethanolic extr...

The effects of a bilateral electrolytical lesion of the CEA on the behavioral and sympathetically induced cardiac response in the shock-probe/defensive-burying test have been analyzed in male Wistar rats. Lesions in the CEA failed to affect defensive burying and accompanying tachycardiac response as compared to sham-lesioned controls during the presentation of the electrified shock probe (uncon...

Obsessive-compulsive disorder (OCD) is characterized by absurd, recurrent thoughts (obsessions) followed by certain stereotyped actions (compulsions). OCD can impair all areas of brain functioning and produce devastating effects on patients and their families. Marble-burying behavior of mice is a well-accepted paradigm to screen anti-compulsive activity. The aim of present study was to evaluate...