introduction: learning and memory deficits in some diseases are new subjects of research. bupropion, as dopamine and noradrenaline reuptake inhibitor and an antidepressant agent, has been previously shown to affect learning and memory processes. this study was designed to test the effect of intra-hippocompal bupropion injection on active avoidance learning task in rats. methods: adult male wist...

Introduction: The most common interpretation for the mechanisms of antidepression is the increase of the brain monoamine levels such as dopamine (DA). The increase of DA can reduce depression but it can also decrease the monoamine release because of autoreceptor inhibition. Although bupropion can decrease the dopamine release, there is evidence about stimulatory effects of chronic application o...

Introduction: Learning and memory deficits in some diseases are new subjects of research. Bupropion, as dopamine and noradrenaline reuptake inhibitor and an antidepressant agent, has been previously shown to affect learning and memory processes. This study was designed to test the effect of intra-hippocompal bupropion injection on active avoidance learning task in rats. Methods: Adult male ...

Introduction: Antidepressants can modulate brain monoamines by acting on pre-synaptic and postsynaptic receptors. Autoreceptors can reduce the monoamines effect on the somatodendritic or pre-synaptic regions despite its postsynaptic counter effects. The direct effect of some antidepressants is related to its temporal and spatial bioavailability in the vicinity of these receptors (still a matter...

objective(s) bupropion is an atypical antidepressant that is widely used in smoke cessation under fda approval. the study of synaptic effects of bupropion can help to finding out its mechanism(s) for stopping nicotine dependence. in this study the effects of perinatal bupropion on the population spike (ps) amplitude of neonates were investigated. materials and methods hippocampal slices were pr...

Introduction: Inflammatory pain is a common sign of chronic diseases. Some brain regions such as locus coeruleus (LC) of the brainstem nor-epinephrine (NE) system have a key role in The mechanisms of the pain modulation and dependence. Bupropion synthesized as an antidepressant, but it is using for smoke cessation. It can change morphine withdrawal signs such as pain related behaviors. This stu...

intraperitoneal (ip) injection of bupropion (3,6, amine (4,16 mg kg•&apos;) induced dose-dependent climbing in mice. the climbing response induced by both drugs were decreased in animals pretreated either with the 0-1 antagonist sch 233<)0 or the 0-2 antagonist sulpiride. the α-adrenoceptor blocker phenoxybenzamine decreased the climbing induced by both bupropion and amphetamine, but the β-adre...

Introduction: Bupropion is currently mainly used as an atypical antidepressant due to its psychotropic effects. In addition, it shows high potential in reducing withdrawal cravings addicts, which also the treatment of nicotinism. However, studies recent years have shown that may be useful other conditions.Aim study: Our aim was review known usage bupropion fields psychiatry, neurology and inter...

Objective(s) Bupropion is an atypical antidepressant that is widely used in smoke cessation under FDA approval. The study of synaptic effects of bupropion can help to finding out its mechanism(s) for stopping nicotine dependence. In this study the effects of perinatal bupropion on the population spike (PS) amplitude of neonates were investigated. Materials and Methods Hippocampal slices were...