نتایج جستجو برای: bsmi polymorphism and vitamin d receptor gene
تعداد نتایج: 17155683 فیلتر نتایج به سال:
Background & Aims: 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3), the biologically active form of vitamin D, exerts an immunosuppressive effect through binding to its specific nuclear receptor. The present case-control study was done to examine the possible association of BsmI polymorphism in vitamin D receptor gene (VDR gene) with severity of multiple sclerosis (MS). Methods: 267 Iranian patients w...
Background & Aims: The hashimoto thyroiditis as a common autoimmune thyroid disease have a multifactorial etiology. Vitamin D status and vitamin D receptor gene BsmI polymorphism are involved in hashimoto developing. The aim of this research was to study the association between 25hydroxy vitamin D serum levels and BsmI polymorphism with hashimoto. Materials & Methods: We conducted a case-contr...
b a ckground: the purpose of our study was to investigate the possible effect of bsm i vitamin d receptor (vdr’s) polymorphism on changes of the inflammatory and oxidative stress (os) biomarkers in response to daily intake of vitamin d- fortified yogurt drink ( doogh ) in subjects with type 2 diabetes (t2d). m ethods : in a randomized controlled trial, 100 t2d subjects were allocated to two g...
Background & Aims: Scleroderma is a chronic connective tissue disease with unknown etiology. Vitamin D, a necessary hormone that plays a particular function in the calcium and phosphate homeostasis, is involved in etiology of this disorder. Klotho, co-receptor of fibroblast growth factor 23 (FGF-23), can interfere in calcium and phosphate metabolism. The purpose of this study was to determ...
Background: Thyroid cancer is the most common endocrine malignancy. Accounting for approximately 1-2% of all cancers. Thyroid cancers have been divided into four main types: papillary, follicular, medullary and anaplastic. The active form of vitamin D (1,25- (OH) 2-vitamin D3) by binding to its receptor, using genomic and non-genomic mechanisms inhibits the proliferative effect of TSH on thyroi...
Background:Previous studies evaluating the association between ApaI, FokI, TaqI, and BsmI polymorphisms of vitamin D receptor gene (VDR) and risk of coronary artery disease (CAD) have produced inconsistent results. The present meta-analysis of eligible studies was conducted to reveal whether this polymorphism plays a role in susceptibility to CAD. Methods: Literature search...
Introduction: Vitamin D fulfills its crucial role in cell proliferation and death through signal transduction into the nucleus by vitamin D receptor (VDR). Recent studies have depicted the association between VDR gene polymorphisms and different cancers, including breast cancer. This study attempted to consider the relationship between VDR gene polymorphisms and breast cancer risk among women i...
Introduction: Vitamin D fulfills its crucial role in cell proliferation and death through signal transduction into the nucleus by vitamin D receptor (VDR). Recent studies have depicted the association between VDR gene polymorphisms and different cancers, including breast cancer. This study attempted to consider the relationship between VDR gene polymorphisms and breast cancer risk among women i...
BACKGROUND The vitamin D receptor (VDR) gene is expressed abundantly in different tissues; including adipocytes and pancreatic beta cells. The rs1544410 or BsmI single nucleotide polymorphism (SNP) in the intronic region of the VDR gene has been previously associated with vitamin D levels, obesity and insulin resistance. AIMS This study was aimed to examine the association between BsmI polymo...
Vitamin D is associated with a wide range of other functions beyond bone development. We evaluated the factors associated with 25-hydroxyvitamin D levels in 974 children aged ≤ 10 years and the impact of BsmI polymorphism of the vitamin D receptor (VDR) gene (rs1544410) on metabolic parameters in a subsample (n: 430) with a follow-up 2 years later from the initial population-based cross-section...
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