PURPOSE To evaluate the association between the BsmI polymorphism and vascular risk factors or metabolic syndrome in patients with epilepsy treated with valproate. METHODS We performed a cross-sectional study to determine glucose homeostasis, lipid profile, and evidence of metabolic syndrome, as well as the BsmI polymorphism in seizure free adults with epilepsy. RESULTS We recruited 75 pati...

The BsmI polymorphism of the vitamin D receptor (VDR) gene influences mineral metabolism and the course of cancers and infections. The poly-A polymorphism is in linkage disequilibrium with BsmI and could be responsible for clinical associations attributed to BsmI. The objective of this work is to study the influence of VDR polymorphisms on survival of 143 prevalent hemodialysis (HD) patients fo...

In this review a strategy for the design of bioinspired, smart, multiscale interfacial (BSMI) materials is presented and put into context with recent progress in the field of BSMI materials spanning natural to artificial to reversibly stimuli-sensitive interfaces. BSMI materials that respond to single/dual/multiple external stimuli, e.g., light, pH, electrical fields, and so on, can switch reve...

To explore the relationship between vitamin D receptor gene (ApaI, BsmI) genotypes and allele frequency and mild cognitive impairment in Xinjiang Uygur population. The polymorphisms of the VDR genotypes (ApaI and BsmI) were analyzed by Snapshot method in 124 MCI patients and 124 controls. A allele of ApaI gene increased the risk of MCI [OR = 1.62, 95% CI (1.13-2.31)]; AA genotype increased the ...

BACKGROUND Vitamin D receptor (VDR) gene polymorphisms are possibly involved in the development of type 1 diabetes mellitus (T1DM). However, the results to date have been inconclusive. We performed a meta-analysis to examine the association between 2 polymorphisms (FokI and BsmI) of the VDR gene and T1DM in the Asian population. METHODS Literature was retrieved from PubMed, Web of Science, CB...

OBJECTIVE Growing evidence has shown that vitamin D deficiency can cause lower bone mineral density (BMD) and an increased risk of osteoporosis. Vitamin D receptor (VDR) BsmI polymorphism (rs1544410) can affect BMD variation and circulating osteocalcin levels. To date, a wide range of epidemiological studies have been carried out to evaluate the association between VDR BsmI polymorphism and sus...

FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated with LVH in ESRD patients, we addressed this study in patients with chronic kidney disease (CKD) no...

We studied three vitamin D receptor gene (VDR) polymorphisms (BsmI, TaqI, FokI) in a case-control study of non-Hodgkin's lymphoma. The BsmI B and TaqI t alleles were associated with an increased risk of diffuse large B-cell lymphoma. These findings suggest that variants in VDR may influence lymphomagenesis.

In previous studies, allelic variation in the 3' end of the vitamin D receptor gene was associated with increased risk of prostate cancer in white men. Several polymorphisms, including a BsmI restriction site and a poly(A) microsatellite, can be used interchangeably to mark the unidentified locus in whites. In African-Americans, however, these markers are not interchangeable, due to weaker link...

Abstract Background Behcet’s disease (BD) is a systemic inflammatory of the blood vessels and affects various body parts. This study aimed to determine association four single-nucleotide polymorphisms (SNPs) BD in Egyptian population using multiple statistical models show resulting associations along with previous studies different populations. Four SNPs were examined for their BD: two from vit...