Asthma and chronic obstructive pulmonary disease (COPD) are characterized by different patterns of airway remodeling, which all include an increased mass of bronchial smooth muscle (BSM). A remaining major question concerns the mechanisms underlying such a remodeling of BSM. Because mitochondria play a major role in both cell proliferation and apoptosis, we hypothesized that mitochondrial activ...

Asthmatic bronchial smooth muscle (BSM) is characterized by structural remodeling associated with mast cell infiltration displaying features of chronic degranulation. Mast cell-derived tryptase can activate protease activated receptor type-2 (PAR-2) of BSM cells. The aims of the present study were (i) to evaluate the expression of PAR-2 in both asthmatic and non asthmatic BSM cells and, (ii) to...

Business Service Management (BSM), rooted in ITIL, helps organizations manage IT from a business perspective. By identifying and mapping business-critical processes to the underlying IT infrastructure and services, BSM connects key business services to the IT services that manage them, such as routers, servers, and applications. While BSM does the mapping, SOA serves as the framework that conne...

Recent studies revealed an involvement of RhoA/Rho-kinase in the contraction of bronchial smooth muscle (BSM), and this pathway has now been proposed as a new target for asthma therapy. A posttranslational geranylgeranylation of RhoA is required for its activation. Thus selective inhibition of geranylgeranyltransferase may be a novel strategy for treatment of the BSM hyperresponsiveness in asth...

Background. Calreticulin controls the C/EBPαp42/p30 at the translational level trough a cis-regulatory CNG rich loop in the CEBPA mRNA. We determined the effects of steroids and long-acting beta-agonists on the p42/p30 ratio and on calreticulin expression in primary human bronchial smooth muscle (BSM) cells. Methods. The effects of budesonide (10(-8) M) and formoterol (10(-8) M) were studied in...

IJPT | July-2013 | Vol. 5 | Issue No.2 | 5567-5573 Page 5567 ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com A COMPARATIVE STUDY ON MICROBIAL GROWTH AND SUBSTRATE UTILIZATION KINETICS Merina Paul Das*, Santosh Kumar Department of Industrial Biotechnology, Bharath University, Chennai, India. Email: [email protected] Received on 02-07-2013 Accepted on ...

We conducted this study to evaluate the combined effect of acellular bladder submucosa matrix (BSM) and autologous urethral tissue for the treatment of long segment urethral stricture in a rabbit model. To prepare the BSM, porcine bladder submucosa was processed, decellularized, configured into a sheet-like shape, and sterilized. Twenty rabbits were randomized to normal control, urethral strict...

Behavioral sleep medicine (BSM) has recently emerged as a subspecialty area within the broader field of sleep medicine. Certain commonly used treatment approaches in BSM were first pioneered in the 1930s, and this article traces the developments within BSM to current practice. Important innovations include the expansion of BSM beyond the treatment of insomnia to include treatment of pediatric s...

Due to the six unreasonable assumptions companioned with the Black-Scholes options pricing model (BSM), which often make the miss-pricing result because of the difference of market convention in practical. This study try to combine the BSM and extended Kalman filters-based artificial neural networks (EKF-ANN) to deal with the limitation of consideration of the influences from many unexpected re...

The effects of sphingosine-1-phosphate (S1P) on bronchial smooth muscle (BSM) contractility were investigated in naive mice. S1P had no effect on the basal tone of the isolated BSM tissues. However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were ...